As an abundant ECM protein, collagen possibly binds with at least five different groups of receptors in biological cells based on the available data. These are integrins, DDR, Glycoprotein VI, Osteoclast-associated receptor (OSCAR), LAIR-1, and uPARAP/Endo180.

Feb 15, 2016 · GPVI is an important collagen-binding immune receptor on platelets, with an activating role that is independent of integrin α2β1 (Marjoram et al., 2014; Zahid et al., 2012). Recent data suggest that it can also bind laminin isoforms …

Jul 23, 2004 · In the integrin family, the collagen receptors form a structurally and functionally distinct subgroup. Two members of this subgroup, alpha(1)beta(1) and alpha(2)beta(1) integrins, are known to bind to monomeric form of type I collagen.

Integrin α1β1 binds to collagen via the MIDAS motif in the α subunit I domain. It preferentially binds collagens IV, VI and type XIII collagen, but also fibril-forming collagens. Specific binding sites in collagen I and IV have been identified. This receptor is …

Feb 15, 2016 · This Commentary discusses the recent development in the field of collagen-binding integrins, their roles in physiological and pathological settings with special emphasis on wound healing, fibrosis and tumor-stroma interactions, and include a discussion of the most recently identified newcomers to this subfamily--integrins α10β1 and α11β1.

Background: Integrin α2β1 is a platelet collagen receptor. Results: Novel sulfonamide derivatives are conformation-selective inhibitors of α2β1, especially when tested under shear stress conditions. Only inhibitors that block non-activated integrins inhibit platelet binding to collagen.

Mar 31, 2000 · The α2β1 integrin recognizes several collagen types. The GFOGER motif occurs only in the α1 strands of the fibrillar collagens, types I and IV. It is likely however that the sequence, GAOGER, residues 511–516 of collagen III, …

Dec 1, 2024 · Integrin α11β1 contributes to cell surface-associated collagen I assembly. Solid epithelial cancers with significant desmoplasia are characterized by an excessive deposition of collagen-based matrix, which often supports tumor progression.

Jul 23, 2004 · Integrin α 2 β 1 Mediates Cell Adhesion to and Spreading on Fibrillar Collagen, Promoting the Formation of Long Cellular Projections—To investigate the importance of specific integrins as functional receptors for fibrillar type I collagen, cells expressing different integrin patterns were examined.

Inactivation of the collagen alpha 1 (I) gene in mice results in embryonic lethality and collagen mutations in humans cause defects leading to disease. Integrins constitute a major group of receptors for extracellular matrix components, including collagens.