Integrin subunits span the cell membrane and have short cytoplasmic domains of 40–70 amino acids. The exception is the beta-4 subunit, which has a cytoplasmic domain of 1,088 amino acids, one of the largest of any membrane protein.

Integrin-engagement triggers the formation of membrane extensions that are required for cell spreading on ECM surfaces, for migration of cells into sheets of other cells, or for engulfment of particles or pathogens by phagocytic cells.

Jan 2, 2023 · Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms, including protein-protein interactions, conformational changes, and...

An integrin molecule is composed of two noncovalently associated transmembrane glycoprotein subunits called α and β (Figure 19-64; see also Figure 19-12B).

Integrin adaptor proteins can be loosely grouped into three categories based on their function, namely, (1) adaptors that have catalytic activity, (2) adaptors that have a structural function and (3) adaptors that form scaffolds for other adaptors to interact and bind with.

Integrins are large, membrane-spanning, heterodimeric proteins that are essential for a metazoan existence. All members of the integrin family adopt a shape that resembles a large “head” on two “legs,” with the head containing the sites for ligand ...

Aug 5, 2007 · The integrin tails recruit several proteins, such as talin, that bind actin filaments, and thus form a connection to the cytoskeleton, a connection that is essential for most, if not all, integrin-mediated functions.

May 24, 2021 · Integrin-mediated cell adhesion is regulated at multiple levels. These include the regulation of integrin expression, ligand availability, heterodimer specificity and activity, and the recruitment of different intracellular proteins.

Sep 20, 2002 · In this review, I will first give a brief overview of the integrin family to set the context and then review the recent structural data and experiments arising from them, which give insight into some long-standing questions concerning integrin functions.

Jan 2, 2019 · Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.