SHIP1 is structured by multiple domain and is encoded by the INPP5D gene in humans. [5] [6] [7] SHIP1 is expressed predominantly by hematopoietic cells [8] but also, for example, by osteoblasts [9] and endothelial cells. [10] This phosphatase is important for the regulation of cellular activation.

Mar 30, 2025 · INPP5D (Inositol Polyphosphate-5-Phosphatase D) is a Protein Coding gene. Diseases associated with INPP5D include Hematologic Cancer and Crohn's Disease. Among its related pathways are Interleukin-2 family signaling and superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism.

Nov 29, 2023 · Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, we find that reduction in INPP5D activity is associated with molecular profiles...

Dec 9, 2024 · The gene inositol polyphosphate-5-phosphatase D (INPP5D), which encodes the lipid phosphatase SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1), is associated with the risk of Alzheimer’s disease (AD). How it influences microglial function and brain physiology is unclear.

Introduction: Mutations in INPP5D, which encodes for the SH2-domain-containing inositol phosphatase SHIP-1, have recently been linked to an increased risk of developing late-onset Alzheimer's disease.

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia. Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia. Human Cytomegalovirus Mediates Unique Monocyte-to-Macrophage Differentiation through the PI3K/SHIP1/Akt Signaling Network.

Nov 30, 2022 · Introduction: The inositol polyphosphate-5-phosphatase D (INPP5D) gene encodes a dual-specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins. Single nucleotide polymorphisms in INPP5D impact risk for developing late onset sporadic Alzheimer's disease (LOAD).

Jan 26, 2024 · Inhibiting microglial AD gene INPP5D activates the inflammasome. In AD brain, INPP5D expression is up, but active protein is down. This triggers the inflammasome, worsening inflammation. In human microglia generated from iPSCs, dunking SHIP1 drove …

Dec 27, 2024 · Title: Expression of INPP5D Isoforms in Human Brain: Impact of Alzheimer's Disease Neuropathology and Genetics. Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases.

Nov 29, 2023 · Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, we find that reduction in INPP5D activity is associated with molecular profiles consistent with disrupted autophagy and inflammasome activation.