UDP-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that metabolize endogenous fatty acids such as arachidonic acid metabolites, as well as many prescription …

Feb 1, 2015 · This review gives an overview of recent findings in UGT and esterases studies focusing on tissue distribution, gene regulation, substrate and inhibitor specificity, and species …

Jun 1, 2013 · UGT is a complex superfamily of enzymes with distinct but overlapping substrate and inhibitor selectivities. These enzymes play essential roles in terminating the biological …

Oct 22, 2024 · This study expands the breadth of biochemical pathways associated with UGT expression and establishes extensive connectivity between UGT enzymes, alt. proteins and …

Jul 10, 2024 · UDP glucuronosyltransferase (UGT) enzymes are responsible for glucuronidation of their substrates (exogenous or endogenous compounds) via covalent linkage (conjugation) …

UGTs are glycosyltransferases that catalyze the covalent binding of glucuronic acid from the high energy donor, UDP-αD-glucuronic acid on structurally related substances with a functionalized …

The UDP-glucuronosyltransferase (UGT) enzymes are critical for regulating nutrients, hormones, and endobiotics, as well as for detoxifying xenobiotics. Human and murine fetuses are known …

UGT reaction phenotyping Stepwise approach •Initial qualitative screen in the recombinant enzymes (UGT 1A1, 1A3, 1A4, 1A6, 1A9, 2B4, 2B7, 2B10, 2B15 and 2B17); •Confirmation of …

Jul 1, 2017 · Glucuronidation catalyzed by UDP-glucuronosyltransferases (UGTs) is one of the most important phase II mechanisms, responsible for around 35% of phase II metabolisms.

UGT1A7, UGT1A8, and UGT1A10 enzymes are expressed mainly in the small intestine and colon and are absent in the liver. Orally administered drugs that are extensively metabolized by …