Hematopoietic stem and progenitor cells (HSPCs) are the progenitor cells that can regenerate the entire blood compartment, including the immune system. Recent studies have unearthed considerable immune‐modulating potential of these cells.

Jan 27, 2022 · In this review, we discuss the research demonstrating the involvement of HSPCs in the onset of long-lasting trained immunity. We highlight the roles of specific cytokines and Toll-like receptor ligands in influencing HSPC memory phenotypes and the molecular mechanisms underlying trained immunity HSPCs.

Mar 31, 2020 · New research suggests that haematopoietic stem cells (HSCs) can contribute to trained immunity. Stimulation with lipopolysaccharide establishes long-lasting epigenetic changes in HSCs that...

Trained immunity induced by injection of β-glucan in mice leads to the expansion of myeloid-biased HSPCs, such as CD41 + LT-HSCs and MPP3 cells, in the BM 98. β-glucan-induced myelopoiesis requires signaling through IL-1β and is associated with enhanced glycolysis and cholesterol biosynthesis in HSPCs.

Understanding the mechanisms and extent of trained immunity induction by pathogens and vaccines, such as BCG, in HSPC remains a critical area of exploration with important implications for health and disease.

Recent studies suggest that infection reprograms hematopoietic stem and progenitor cells (HSPCs) to enhance innate immune responses upon secondary infectious challenge, a process called “trained immunity.” However, the specificity and cell types responsible for this response remain poorly defined.

In this review, we will highlight recent progress in our understanding of vector–host interactions and innate immunity in HSPC and discuss how dissecting this crosstalk can guide the development of more stealth and efficient gene therapy approaches in the future.

Nov 23, 2021 · When innate immune cells and hematopoietic stem and progenitor cells (HSPCs) are exposed to pathogenic agents, they develop heightened responses to subsequent infection through a process called trained immunity.

Apr 1, 2025 · Allogeneic transplantation of CCR5 null hematopoietic stem and progenitor cells (HSPCs) is the only known cure for HIV-1 infection. However, this treatment is limited because of the rarity of CCR5 ...

HSPC can respond to infection and inflammation by expansion in the bone marrow, mobilization to the circulation and peripheral tissue, proliferation, differentiation, and elaboration of secreted factors. HSPC thus may fine-tune the innate immune response.