Jan 15, 2025 · Matrix metalloproteinases (MMPs) are endopeptidases that depend on calcium and zinc and are essential in numerous biological processes. The first known MMP was an interstitial collagenase (MMP1), which was identified in …

Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing endopeptidases; [1] other family members are adamalysins, serralysins, and astacins.

MMPs are the most important enzymes for ECM maintenance. They are also involved in several biological and pathological diseases. However, MMPs remain a challenge for science, due to their high complexity, both in terms of regulation and activity.

Nov 1, 2017 · Matrix metalloproteinases (MMPs) are multi-functional enzymes in inflammation. Both acute and chronic inflammation can be regulated by MMP activity. Some MMPs can play both beneficial and detrimental roles at different stages. MMPs control inflammation as soluble factors, at cell surfaces and even in nuclei.

Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Recent work has...

Oct 10, 2018 · Matrix metalloproteinases (MMP) are involved in plaque progression and destabilisation and are therefore promising targets to characterize rupture-prone unstable plaques. This study aims at evaluating MMP imaging to …

Matrix metalloproteinases (MMPs) constitute a family of 24 mammalian extracellular or membrane-bound proteinases that function in wound repair, mucosal defence, inflammation and acquired...

Jun 28, 2012 · We investigated the use of a new MMP activatable probe MMPSense ™ 750 FAST (MMPSense750) for in-vivo visualization of early MMP activity in ischemic stroke. Following middle cerebral artery occlusion (MCAO) optical imaging was performed.

Apr 4, 2005 · We used a molecular probe activated by protease cleavage to image expression of matrix metalloproteinases (MMPs) in the heart following myocardial infarction. We synthesized and characterized a near-infrared fluorescent (NIRF) probe that is activated by proteolytic cleavage by MMP2 and MMP9.

Jan 15, 2024 · Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that belong to the group of endopeptidases or matrixins. They are able to cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targe …