Regulation of the IL-5 receptor alpha (IL5RA) gene is complicated, with two known promoters (P1 and P2) driving transcription, and two known isoforms (transmembrane and soluble) dichotomously affecting the signaling potential of the protein products.

We analyzed IL5RA expression, the gene expression profile, and secretory protein genes related to IL5RA level using GEO data. Immunogenic cell death subgroup classification was performed using the ConsensusClusterPlus and pheatmap R package.

Aug 19, 2022 · Interleukin 5 (IL-5) plays crucial roles in type 2-high asthma by mediating eosinophil maturation, activation, chemotaxis and survival. Inhibition of IL-5 signaling is considered a strategy for...

Sep 23, 2021 · Regulation of the IL-5 receptor alpha (IL5RA) gene is complicated, with two known promoters (P1 and P2) driving transcription, and two known isoforms (transmembrane and soluble) dichotomously affecting the signaling potential of the protein products.

Dec 1, 2005 · IL5 stimulates the release of eosinophils into the circulation and prolongs their survival via the specific alpha subunit of interleukin 5 receptor (IL5RA on 3p26-p24) expressed on eosinophils...

Mar 30, 2025 · IL5RA (Interleukin 5 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL5RA include Pancreatic Vasoactive Intestinal Peptide Producing Tumor and Hypereosinophilic Syndrome. Among its related pathways are MAPK family signaling cascades and Interleukin-2 family signaling.

Jul 9, 2024 · We obtained single-cell resolution of eosinophilopoiesis by combining single-cell proteomic screening by flow cytometry, generating a transgenic IL-5Rα reporter mouse strain and (single-cell) transcriptomic analyses.

Jul 9, 2024 · We combined single-cell proteomics and transcriptomics and generated transgenic IL-5Rα reporter mice to revisit eosinophilopoiesis. We reconciled human and murine eosinophilopoiesis and provided extensive cell-surface immunophenotyping and transcriptomes at different stages along the continuum of eosinophil maturation.

Sep 23, 2021 · Regulation of the IL-5 receptor alpha (IL5RA) gene is complicated, with two known promoters (P1 and P2) driving transcription, and two known isoforms (transmembrane and soluble)...

Gene Ontology (GO) annotations organized by slimming set. Membrane ; Single-pass type I membrane protein. Showing features for topological domain, transmembrane. Showing features for natural variant. We now provide the "Disease & Variants" viewer in its own tab.