- Copilot AnswerFunction
Interleukin 4 has many biological roles, including the stimulation of activated B cell and T cell proliferation, and the differentiation of B cells into plasma cells. It is a key regulator in humoral and adaptive immunity. … See more
Interleukin-4 supports interleukin-12-induced proliferation and ...
Interleukin-12 (IL-12) and IL-4 are known to differentially promote T helper (Th) cell differentiation. While IL-12 induces interferon-γ (IFN-γ) production and maturation of Th1 cells, IL-4 is thought …
Pro-Inflammatory Cytokines Overview - Thermo Fisher …
IL-12 and IL-8 are other cytokines that are produced to enhance the IFN-γ production which attracts monocytes and T lymphocytes but not neutrophils (in SARS-CoV-2), in order to induce apoptosis and eliminate the infected cells.
Regulation of LPS induced IL-12 production by IFN-γ and IL-4 …
We found that IL-4 and IFN-γ affected the balance of intracellular GSH/oxidized glutathione (GSSG) and suggest that this balance regulates the amount of IL-12 secreted by …
The biology of IL-12: coordinating innate and adaptive immune …
Oct 1, 2003 · IL-12 induces interferon-γ (IFN-γ) production by NK, T cells, dendritic cells (DC), and macrophages. IL-12 also promotes the differentiation of naı̈ve CD4 + T cells into T helper 1 …
- Author: Wendy T Watford, Masato Moriguchi, Akio Morinobu, John J O’Shea
- Publish Year: 2003
Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by ...
Our data showed that IL-4 up-regulates IL-12 while inhibiting IL-10 production by DCs, but not by B cells. The inhibition of IL-10 by IL-4 appears necessary for the induction of Th1 cell …
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The Immunobiology of the Interleukin-12 Family: …
The IL-12 family of cytokines influences the outcome of cancer, infection, and inflammatory diseases. Stumhofer, Hunter, and Tait review the combinatorial …
- Author: Elia D. Tait Wojno, Christopher A. Hunter, Jason S. Stumhofer
- Publish Year: 2019
Interleukin 12 - Wikipedia
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, [1] macrophages, neutrophils, helper T cells and human B- lymphoblastoid cells (NC-37) in …
IL-4 Inhibits the Production of TNF-α and IL-12 by STAT6 …
May 1, 1999 · We report here that the inhibitory effects of IL-4 on the production of TNF-α or IL-12 by macrophages had both STAT6-dependent and -independent components, depending on …
A Review of the New Cytokines: IL-4, IL-6, IL-11, and IL-12
Interleukin-4, secreted by activated T-cells, has shown antitumor activity in vitro against multiple myelomas, lymphoma, chronic myelomonocytic leukemia, and some solid tumors.
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