Humans with elevated interleukin (IL) 4, such as is common with aging, 1 asthma, 2 and scleroderma, 3,4 are at high risk of cardiac fibrotic remodeling and dysfunction. 5,6 Certain alleles, genotypes, and haplotypes in IL-4 genes are overexpressed in some patients with ischemic heart failure (HF). 7 Likewise, Balb/c mice have high IL-4 and ...

Emerging studies in both proregenerative and nonregenerative cardiac injury models have revealed a role for two cytokines, interleukin 4 (IL4) and interleukin 13 (IL13), as proreparative factors in the heart (3, 4).

Nov 1, 2022 · Emerging literature has identified various roles for IL4/13 in animal models of cardiac regeneration as well as in the adult mammalian heart following myocardial injury.

Elevated interleukin-4 (IL-4) levels are associated with cardiac fibrosis in hypertension and heart failure in both patients and experimental animals. We hypothesized that chronically elevated IL-4 induces cardiac fibrosis, resulting in a predisposition of …

Jul 31, 2017 · Recent research has shown that reparative (alternatively activated or M2) macrophages play a role in repair of damaged tissues, including the infarcted hearts. Administration of IL-4 is known to...

Dec 16, 2020 · Mechanistic studies reveal roles of eosinophil IL4 and cationic protein mEar1 in blocking H 2 O 2 - and hypoxia-induced mouse and human cardiomyocyte death, TGF-β-induced cardiac fibroblast...

IL-4, an immunoregulatory cytokine, plays a role in various cellular pathways and is known to regulate M2 macrophage polarization. Numerous studies have suggested that promoting the polarization of macrophages toward the M2 phenotype …

Jun 22, 2022 · cellular actions of IL4/13 in the heart is still lacking, but overall evidence to date suggests that activation of these cytokines results in beneficial outcomes with respect to cardiac repair. Here, we aim to comprehensively review the role of IL4 and IL13 and their prospective mechanisms in cardiac regeneration and repair.

Multivariate logistic regression analysis indicated that two serum cytokines (IL-4 and IL-17), one protective factor (high-density lipoprotein cholesterol [HDL-C]), and three risk factors (sex, smoking, and diabetes) were independently predictive of CAD.

Apr 12, 2024 · Here, our observational study demonstrates that humans taking the IL4Rα neutralizing antibody, dupilumab, have increased incidence of heart failure following an ischemic event. Similarly, global IL4Rα deletion in mice exacerbates heart failure postinfarct.