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    Nature
    https://www.nature.com › articles

    Ligand-induced type II interleukin-4 receptor dimers are ... - Nature

    • The spatiotemporal organization of cytokine receptors in the plasma membrane is still debated with models ranging from ligand-independent receptor pre-dimerization to ligand-induced receptor dimerizat… See more

    Introduction

    Cytokines are first messenger proteins with key functions in immunity and haematopoiesis. … See more

    Nature
    Results

    Dimerization critically depends on receptor densities
    We characterized the molecular features of the type II IL-4 receptor assembly under well-define… See more

    Nature
    Discussion

    With its critical implication in allergy, asthma and cancer, the type II IL-4 receptor is an important drug target28,29. For efficient pharmaceutical targeting of receptor ac… See more

    Nature
    Methods

    Plasmid constructs
    IL-13 wt, all IL-4 variants and both receptor ectodomains were fused to an N-terminal ybbR-tag (sequence DSLEFIASKLA) for site-specifi… See more

    Nature
    How does IL-4R bind to a ligand?
    Upon binding to its ligand, IL-4Rα dimerizes either with the common gamma chain (γc) to produce the type-1 signaling complex located mainly on hematopoietic cells, or with the IL-13 receptor alpha 1 (IL-13Rα1) to produce the type-2 complex, which is expressed also on non-hematopoietic cells (14, 15).
    pmc.ncbi.nlm.nih.gov
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