Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. [5] Interleukin 33 is a member of the IL-1 family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL-4).

Mar 30, 2025 · IL33 (Interleukin 33) is a Protein Coding gene. Diseases associated with IL33 include Autoimmune Pancreatitis and Prostate Cancer. Among its related pathways are IL-1 Family Signaling Pathways and Constitutive Signaling by Aberrant PI3K in Cancer. Gene Ontology (GO) annotations related to this gene include cytokine activity.

Jan 8, 2021 · Interleukin (IL)-33 is a cytokine that appears to mediate fibrosis by signaling via its receptor ST2 (IL-33R/IL1RL1). It is also, however, a protein that after synthesis is sorted to the cell...

Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic inflammation, viral infection, and cancer.

Mar 8, 2022 · Our findings suggest that K27-linked polyubiquitination and deubiquitination of IL-33R by TRAF6 and USP38 reciprocally regulate IL-33R level and signaling, which represents a critical mechanism in the regulation of IL-33–triggered lung …

Interleukin-33 (IL-33) is a tissue-derived nuclear cytokine from the IL-1 family abundantly expressed in endothelial cells, epithelial cells and fibroblast-like cells, both during homeostasis and inflammation.

Sep 19, 2016 · Interleukin-33 (IL-33), which was identified as a member of the IL-1 family approximately 10 years ago 1, is now recognized to have a key role in innate and adaptive immunity, contributing to...

IL-33 is a barrier tissue-expressed IL-1 family member 1 that when released targets IL-1 Receptor-Like 1 (IL1RL1), more commonly referred to as ST2, to promote Th2 responses in T cells, mast cells, eosinophils, basophils, and innate lymphoid cell (ILC) populations 2 - 6.

For many years, the interleukin-1 receptor family member ST2 was an orphan receptor that was studied in the context of inflammatory and autoimmune disease. However, in 2005, a new cytokine — interleukin-33 (IL-33) — was identified as a functional ligand for ST2.

Members of the interleukin (IL)-1 family regulate a plethora of immune-cell-mediated processes, which include pathogen defense and tissue homeostasis. Notably, the IL-1 family cytokine IL-33 promotes adaptive and innate type 2 immune responses, confers viral protection and facilitates glucose metabolism and tissue repair.