Interleukin-3 signals through multiple isoforms of Stat5 - PMC
Interleukin-3 signals through multiple isoforms of Stat5. The interleukin (IL)-3 family of cytokines mediates its numerous effects on myeloid growth and maturation by binding a family of related …
IL-3 signaling and the role of Src kinases, JAKs and …
May 25, 2000 · Tyrosine phosphorylation and activation of STAT proteins can be achieved either by JAKs or Src-kinases depending on the nature of STAT that …
- Author: E Premkumar Reddy, Anita Korapati, Priya Chaturvedi, Priya Chaturvedi, Sushil Rane
- Publish Year: 2000
E3 ubiquitin ligase RNF128 negatively regulates the IL-3/STAT5 ...
May 3, 2024 · Here, we identified the E3 ubiquitin ligase RNF128 as a negative regulator of IL-3/STAT5 signaling by targeting IL-3Rα for lysosomal degradation. RNF128 was shown to …
Signaling through JAK2-STAT5 pathway is essential for IL-3
Jan 15, 2004 · Signaling through its receptor, IL-3 induces the activation of JAK-STAT and MAP kinase pathways in microglial cells. In this study, we found that in vitro treatment of EOC-20 …
- Author: John J. Bright, Chandramohan Natarajan, Subramaniam Sriram, Gladson Muthian
- Publish Year: 2004
IL-3 Differentially Regulates Membrane and Soluble RANKL in …
Jan 15, 2018 · IL-3 regulates RANKL expression through the JAK2/STAT5 pathway. Cells were cultured for 0, 15, 30, 60, and 120 min in the presence of IL-3 (100 ng/ml) and activation of …
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Erythropoietin Induces Tyrosine Phosphorylation of the Interleukin …
Jun 15, 1997 · In the present study, we demonstrate that Epo stimulation induces unidirectional cross-phosphorylation of the IL-3 receptor β subunit (β IL3) on tyrosines and its rapid and …
The IL-3, IL-5, and GM-CSF common receptor beta chain mediates ... - Nature
Nov 8, 2021 · It is known that IL-3, IL-5, and GM-CSF-dependent STAT5 phosphorylation requires phosphorylation of JAK2 and CSF2RB, the common beta chain of IL-3, IL-5, and GM-CSF …
STAT5 is a key transcription factor for IL-3-mediated ... - PubMed
Aug 3, 2016 · Here we demonstrate that the activation of signal transducers and activators of transcription 5 (STAT5) by IL-3 inhibits RANKL-induced osteoclastogenesis through the …
Il-3 Signaling In The Basophil: Stat5 - Journal of Allergy and …
RESULTS: Stimulation of the basophils with IL-3 induced a phosphorylation of STAT5, which was 5 times higher than basal value. rBet v 1 alone did not elicit STAT5 phosphorylation. …
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