Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene. [5] . Also known as CD122; IL15RB; P70-75. [5] The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2.

Mar 30, 2025 · IL2RB (Interleukin 2 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL2RB include Immunodeficiency 63 With Lymphoproliferation And Autoimmunity and Ichthyosis. Among its related pathways are TGF-Beta Pathway and MIF Mediated Glucocorticoid Regulation.

The IL2RB mutation leads to a deletion in the WSXWS motif, resulting in reduced IL-2Rβ expression and dysregulated downstream signaling. As might be expected for a defect in IL-2 signaling, this mutation clinically mirrors an IPEX-like syndrome.

Interleukin 2 receptor subunit beta as a novel hub gene plays a potential role in the immune microenvironment of abdominal aortic aneurysms. Soluble IL-2R Levels at Baseline Predict the Development of Severe Respiratory Failure and Mortality in COVID-19 Patients.

Aug 8, 2018 · With the cloning of IL-2 receptor α-chain (IL-2Rα, encoded by IL2RA; also known as CD25) 5,6 and then IL-2Rβ (encoded by IL2RB; also known as CD122) 7, it became clear that IL-2Rα 5 lacks a ...

Sep 5, 2016 · Regulatory T cells (T reg cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role...

IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. (Microbial infection) Interacts with HTLV-1 accessory protein p12I.

Here we identify human interleukin-2 receptor (IL-2R) β chain (IL2RB) gene defects as a cause of life-threatening immune dysregulation. We report three homozygous mutations in the IL2RB gene of eight individuals from four consanguineous families that cause disease by distinct mechanisms.

IL2RB is a prognostic marker in Kidney renal papillary cell carcinoma, Skin cuteneous melanoma

Jul 9, 2019 · The IL2RB gene encodes the beta subunit of the interleukin-2 (IL2) receptor, which transmits signals from the cytokines IL2 (147680) and IL15 (600554). IL2RB shows constitutive or induced expression on various types of immune cells, including CD4+ T regulatory cells, CD4+ and CD8+ T cells, B cells, and NK cells (summary by Zhang et al., 2019).