Mar 30, 2025 · Complete information for IL18R1 gene (Protein Coding), Interleukin 18 Receptor 1, including: function, proteins, disorders, pathways, orthologs, and expression.

IL18R1 is also known as CDw218a (cluster of differentiation w218a). The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction.

Dec 11, 2023 · IL-18 is an IL-1 family cytokine with potent ability to induce IFNγ production. However, basic investigations and now clinical observations suggest a more complex picture.

Interleukin 18 (IL18) receptor 1 (IL18R1), also known as IL18RA, encodes a cytokine receptor. The receptor encoded by IL18R1 specifically binds to IL18, thereby exerting biological effects. T cytotoxic cells are known as CD8 + T cells. IL18R1 is the surface marker of CD8 + T cells (6). IL18R1 plays an important role in cancer progression (7 – 10).

Feb 8, 2025 · Downregulation of T-cell cytotoxic marker IL18R1 promotes cancer proliferation and migration and is associated with dismal prognosis and immunity in lung squamous cell carcinoma.

Declines in renal function correlate with elevated circulating pro-inflammatory cytokines in patients with these conditions. The inflammasome is an important inflammatory signalling platform that has been associated with low-grade chronic inflammatory diseases.

Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate and acquired immune response. IL-18 is produced by both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes and mesenchymal cell.

Dec 5, 2022 · The IL18R1 expression was downregulated in the LUSC tissues. The IL18R1 expression downregulation was associated with diagnosis and short overall survival and disease-specific survival, and it was also an independent risk factor for dismal survival time in LUSC.

Nov 1, 2022 · IL-18 is formed intracellularly as a 24 kDa inactive precursor protein, pro-IL-18, which requires processing into its active form via the proteolytic actions of a family of innate signalling complexes termed inflammasomes (Dinarello, Novick, Kim, & Kaplanski, 2013; Jha & Ting, 2009; Schroder, Zhou, & Tschopp, 2010).

Mar 4, 2015 · Here we demonstrate that IL-18R1 expression is enhanced on both effector and regulatory CD4 + T cells in the intestinal lamina propria, with T helper type 17 (Th17) cells exhibiting...