Nov 28, 2018 · In this study, we performed single-cell RNA sequencing (scRNA-seq) to determine the heterogeneity among IL-10-secreting CD4 T cells during persistent viral infection. …

IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory …

Feb 8, 2025 · Extracellular HIV-1 Nef induces interleukin (IL)-10 mRNA expression in human PBMCs as well as in H9 T and U937 promonocytic human cell lines; release of IL-10 into …

The chromatin structure of tightly regulated genes such as IL-10 are dynamically regulated by a process called “chromatin remodeling” to create accessibility to the gene by transcription …

Nov 10, 2021 · IL-10 mRNA engineered MSCs (eMSCs-IL10) maintained high levels of IL-10 expression even after freezing and thawing. IL-10 mRNA transfection did not appear to alter …

Oct 25, 2021 · In this study, we have developed a nano-system to deliver inflammation-responsive Il-10 mRNA preferentially into macrophages for tailored inflammation control.

Nov 28, 2018 · To determine the transcriptional changes that underlie this adaption process, we applied a single-cell RNA-sequencing approach and assessed the heterogeneity of IL-10 …

Feb 15, 2010 · Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage …

In this review, we discuss modes of regulation of IL-10 gene expression in immune effector cell types, including signal transduction, epigenetics, promoter architecture, and post …

In this study, we performed single-cell RNA sequencing (scRNA-seq) to determine the heterogeneity among IL-10-secreting CD4 T cells during persistent viral infection. …