In the present review article, we discuss the evidence for the production of IL-10 by glia, and describe the ability of CNS cells, including microglia and astrocytes, to respond to this suppressive factor.

In the course of CNS pathology, the levels of IL-10 significantly increase in the brain in order to ensure nervous tissue survival and mitigate inflammatory responses triggering several signaling pleiotropic pathways .

It is now evident that IL-10 also acts in nonhematopoietic cells, where it plays important homeostatic roles. An example of this comes from central nervous system (CNS) and peripheral nervous system cells, which respond to IL-10 and other IL-10 family members (reviewed in Lobo-Silva et al., 2016; Burmeister and Marriott, 2018). In this context ...

Nov 24, 2016 · Interleukin (IL)-10, an anti-inflammatory cytokine, prevents immunopathology in several diseases and disease models, both in the periphery and in the CNS. Here, we review the current knowledge on the molecular mechanisms regulating IL-10 production by microglial cells and astrocytes and how that balances the immune response in the CNS.

Interleukin (IL)-10 is synthesized in the central nervous system (CNS) and acts to limit clinical symptoms of stroke, multiple sclerosis, Alzheimer's disease, meningitis, and the behavioral changes that occur during bacterial infections.

Nov 27, 2018 · In the present review article, we discuss the evidence for the production of IL-10 by glia, and describe the ability of CNS cells, including microglia and astrocytes, to respond to this suppressive factor.

Our study confirmed that IL-10 is a useful biomarker for the diagnosis of PCNSL. We highlight new findings showing that the IL-10 level in the CSF could be used as a surrogate marker for CSF involvement and that the post-treatment IL-10 concentration could complement standard MRI for therapeutic res …

Jul 7, 2012 · IL10 can regulate genes inhibiting cell cycle progression. In accordance with this, we observe that WT T cells proliferate less rapidly than IL10Rα Tdel cells in the CNS in vivo. Implicitly, IL10 is acting to restrain autoreactive T cell expansion.

Oct 12, 2020 · Single cell transcriptome analysis revealed various IL-10 producing immune cells in the CNS, including most prominently Ly49D + NK cells and neutrophils, but not microglia.

Coordinated interactions between cytokine signaling and morphological dynamics of microglial cells regulate neuroinflammation in CNS injury and disease. We found that pro-inflammatory cytokine gene expression in vivo showed a pronounced recovery ...