Metabolic reprogramming of terminally exhausted CD8 - Nature
May 24, 2021 · Our results provide preclinical evidence that IL-10–Fc is a safe and highly effective therapy that acts on a specific subset of CD8 + TILs distinct from those responding to ICBs. …
Treg cell IL-10 and IL-35 exhaust CD8+ T cells in tumors - Nature
Apr 22, 2019 · Through the use of mouse models of melanoma and thymoma, the authors show that the deletion of IL-10 and/or IL-35 in T reg cells leads to reduced tumor growth and a …
Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8
Jun 10, 2019 · Increasing evidence demonstrates that interleukin-10 (IL-10), known as an immunosuppressive cytokine, induces antitumor effects depending on CD8 + T cells. …
Immune regulation and cytotoxic T cell activation of IL-10 agonists ...
The expansion and activation of tumor antigen reactive CD8+ T cells are primary goals of immunotherapies for cancer. IL-10 is an anti-inflammatory cytokine with an essential role in the …
Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8 - PubMed
Jun 10, 2019 · Increasing evidence demonstrates that interleukin-10 (IL-10), known as an immunosuppressive cytokine, induces antitumor effects depending on CD8 + T cells. …
IL-10 Directly Activates and Expands Tumor-Resident CD8
Jul 15, 2012 · Here we show that treatment with the pleiotropic cytokine interleukin-10 (IL-10) induces specific activation of tumor-resident CD8 + T cells as well as their intratumoral …
Interleukin 10 enhanced CD8+ T cell activity and reduced CD8
Nov 15, 2017 · Blocking IL-10 resulted in higher apoptosis, fewer IFN-γ + CD8 + T cells, and lower Bcl-2 expression. IL-10 also significantly increased STAT3, but not STAT1, …
Inhibitory and Stimulatory Effects of IL-10 on Human CD8
Apr 1, 1998 · We report that IL-10 inhibits alloantigen-specific proliferative responses and induces a long lasting anergic state in human purified CD8 + T cells when added concomitantly with …
Interleukin-10 Directly Inhibits CD8 - Cell Press
Smith et al. demonstrate that during chronic infections, IL-10 upregulates N-glycan branching on CD8+ T cell surface glycoproteins, which reduces signal transduction downstream of the T cell …
Regulation of IL-10 expression and function by JAK-STAT in CD8
Feb 15, 2024 · IL-10 enhances the function of CD8 + T cells through JAK3-STAT6 signaling pathway. IL-10 is a pleiotropic cytokine that plays a significant role in antiviral and antitumor …