The IL-5 receptor (IL-5R) belongs to the type I cytokine receptor family and is a heterodimer composed of two polypeptide chains, one α subunit, which binds IL-5 and confers upon the receptor cytokine specificity, and one β subunit, which contains the signal transduction domains.

IL-5Rα expression in activated B cells is regulated by a complex of transcription factors including E12, E47, Sp1, c/EBPβ, and Oct2. IL-5 signals are transduced through JAK–STAT, Btk, and Ras/Raf-ERK signaling pathways and lead to maintenance of survival and functions of B …

IL-5 binds to the α subunit of IL-5 receptor (IL-5Rα), thereby inducing its interaction with βc subunits and the following activation of a complex intracellular signaling network, consisting of JAK1/2-STAT1/3/5 modules, p38 and ERK MAP kinases, and NF-κB transcription factor.

Jan 8, 2019 · Anti-interleukin-5 therapy is approved for patients with refractory asthma with an eosinophilic phenotype. The severe asthma care team at Mayo Clinic has expertise in identifying appropriate patients for this step-up therapy.

Oct 9, 2009 · Over-expression of IL-5 significantly increases eosinophil numbers and antibody levels in vivo. Conversely, mice lacking a functional gene for IL-5 or the IL-5 receptor alpha chain (IL-5Rα) display a number of developmental and functional impairments in …

Interleukin 5 is a 13-amino acid protein that forms a 52-kDa homodimer related to both granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-3. It binds to a heterodimer receptor on eosinophils formed by the α subunit (IL-5Ra) and the βc subunit, which is shared with the IL-3 and GM-CSF receptors (16).

This article reviews the role of eosinophils in the pathogenesis of bronchial asthma and discusses the potential advantageous biologic effects of benralizumab in comparison with other monoclonal antibodies targeting the IL-5 ligand.

Dec 16, 2019 · IL-5 binds to the α subunit of IL-5 receptor (IL-5Rα), thereby inducing its interaction with βc subunits and the following activation of a complex intracellular signaling network, consisting of JAK1/2-STAT1/3/5 modules, p38 and ERK MAP kinases, and NF-κB transcription factor.

The wide variety of anti-IL-5 antagonists or IL-5 receptor blockers allow to have alternative treatment options for patients with severe hypereosinophilic patients. All the three drugs herein reviewed displayed a good safety profile, and a favorable clinical efficacy in the selected patients.

Dec 22, 2010 · The IL-5 receptor (IL-5R) is a high-affinity receptor expressed on eosinophils, basophils, and mast cells and occurs as a heterodimer of IL-5Rα with the β subunit common to IL-5, IL-3, and GM-CSF receptors. 1 Data from numerous studies in animals and humans have demonstrated that IL-5 signaling through this receptor is essential for ...