Interleukin 31 - Wikipedia
Interleukin-31 (IL-31) is a protein that in humans is encoded by the IL31 gene that resides on chromosome 12. [5][6][7] IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. [7][8]
IL-31: State of the Art for an Inflammation-Oriented Interleukin
IL-31 targeting has proven to be a safe and convenient method to treat itching, and it also has shown some potential in treating oncological diseases and a plethora of inflammatory conditions that could lead to organ failures, such as hepatitis and sepsis.
Interleukin-31: The "itchy" cytokine in inflammation and therapy
IL-31 is a critical cytokine involved in neuroimmune communication, which opens new avenues for cytokine modulation in neuroinflammatory diseases including AD/pruritus, as validated by recent clinical trials using an anti-IL-31 antibody.
Interleukin-31 Signaling Bridges the Gap Between Immune …
Recently, Interleukin (IL)-31 and its receptor complex attracted significant interest, as clinical phase two studies demonstrated therapeutic efficacy of the neutralizing IL-31 receptor A (IL-31RA) antibody nemolizumab in patients suffering from atopic dermatitis or prurigo nodularis.
Structures and biological functions of IL-31 and IL-31 receptors
IL-31 acts on a broad range of immune- and non-immune cells and therefore possesses potential pleiotropic physiological functions, including regulating hematopoiesis and immune response, causing inflammatory bowel disease, airway hypersensitivity and dermatitis.
Interleukin-31: The “itchy” cytokine in inflammation and therapy
In AD, IL-31 has been identified as one of the main “drivers” of its cardinal symptom, pruritus. Here, we summarize the mechanisms by which IL-31 modulates inflammatory and allergic diseases.
The IL-31/IL-31 receptor axis: general features and role in …
IL-31 is a recently identified cytokine with a well-defined role in the pathogenesis of pruritus. IL-31, whose production is induced by IL-4 and IL-33, binds a heterodimeric receptor (R) composed of the exclusive IL-31RA chain and the shared oncostatin M …
IL-31: A new key player in dermatology and beyond - PubMed
IL-31 is a novel cytokine expressed in many human tissues and involved mainly in T H 2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor α and oncostatin M receptor β. The available data show that IL …
Interleukin 31 - an overview | ScienceDirect Topics
IL-31 is a 24 kDa four-helix bundle belonging to the IL-6/gp130 family that binds to the heterodimeric IL-31Rα/oncostatin M receptor-β receptor. From: Cytokine, 2021
IL31 Gene - GeneCards | IL31 Protein | IL31 Antibody
Mar 30, 2025 · IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes.