IL-18 plays a significant role in the activation of hematopoietic cell types mediating both Th1 and Th2 responses and is the primary inducer of interferon-γ in these cells.

Oct 15, 2000 · This study is the first report showing a role for IL-18 in NF-κB and AP1 activation and IL-2 gene expression in sarcoidosis. We have shown that NF-κB was activated and localized to the nucleus of sarcoid but not control respiratory ELF CD4 + T lymphocytes.

Because IL-18 induced AP-1 DNA binding activity, we investigated whether AP-1 complexes interact in vivo with the MMP9 promoter. We therefore performed ChIP assays on arterial SMCs that were...

IL-18-mediated signaling acts as one of the vital components of the immunomodulatory cytokine networks involved in host defense, inflammation, and tissue regeneration. Albeit its biomedical importance, a comprehensive resource of IL-18 mediated signaling pathway is currently lacking.

Dec 11, 2023 · Several new discoveries have revived interest in the pathogenic potential and possible clinical roles of IL-18. IL-18 is an IL-1 family cytokine with potent ability to induce IFNγ...

IL-18 forms a signaling complex by binding to the IL-18 alpha chain (IL-18Rα). The co-receptor, termed IL-18 receptor beta chain (IL-18Rβ), is recruited to form a high affinity complex.

Jul 27, 2013 · The IL-18 receptor and downstream signaling events. The IL-18 receptor (IL-18R) is a heterodimer consisting of IL-18Rα and β chains. IL-18Rα was first identified using a Hodgkin’s disease cell line (L428), which bound rIL-18 and was different from the IL-1β receptor.

IL-18, a member of the IL-1 family, is similar to IL-1β for being processed by caspase 1 to an 18 kDa-biologically active mature form. IL-18 binds to its specific receptor (IL-18Rα, also known as IL-1R7) forming a low affinity ligand chain. This is followed by recruitment of the IL-18Rβ chain.

Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against infections and regulates the innate and acquired immune response. IL-18 is produced by both hematopoietic and non-hematopoietic cells, including monocytes, macrophages, keratinocytes and mesenchymal cell.

Oct 1, 2011 · This study shows that the Nlrc4 inflammasome mediates the clearance of flagellated bacteria, whereas IL-1β and IL-18 are not sufficient. This provides additional evidence of a role for caspase-1 that is independent of IL-1β and IL-18, this time in …