Feb 23, 2018 · Huang et al. identify IGF2BPs as an additional class of N6-methyladenosine (m6A) reader proteins. They find that IGF2BPs selectively bind to m6A-containing mRNAs and promote their stability.

Here, we report the insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; including IGF2BP1/2/3) as a distinct family of m 6 A readers that target thousands of mRNA transcripts through recognizing the consensus GG (m 6 A)C sequence.

Apr 9, 2025 · Insulin-like growth factor 2 messenger RNA (mRNA)-binding protein 2 (IGF2BP2) is a widely studied N 6-methyladenosine (m 6 A) modification reader, primarily functioning to recognize and bind to m 6 A modification sites on the mRNA of downstream target genes, thereby enhancing their stability. Previous studies have suggested that the IGF2BP2-m 6 A modification plays an essential role in ...

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP) are newly identified m 6 A ‘readers’. They belong to a family of RNA-binding proteins, which bind to the m 6 A sites on different RNA sequences and stabilize them to promote cancer progression.

Mar 1, 2024 · Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP) are newly identified m6 A ‘readers’. They belong to a family of RNA-binding proteins, which bind to the m 6A sites on different RNA sequences and stabilize them to promote cancer progression.

Here we report the insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; including IGF2BP1/2/3) as a distinct family of m 6 A readers that target thousands of mRNA transcripts through recognizing the consensus GG (m 6 A)C sequence.

Jul 29, 2021 · IGF2BPs in turn regulated sphingosine-1-phosphate receptor 3 (S1PR3) expression in an m 6 A-dependent manner by enhancing the stability of S1PR3 mRNA. They also promoted kidney...

Feb 20, 2025 · IGF2BP1 could promote the expression of cancer-related genes by recognizing their m6A sites, thereby altering cell characteristics, and eventually, malignancy. Therefore, IGF2BP1 might be a potential target for tumor diagnosis and anti-tumor therapeutic strategies.

Apr 5, 2025 · Specifically, PHGDH stabilizes TCF7L2 mRNA by interacting with insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1), a key m6A reader, in an m6A-dependent manner, thereby increasing the ...

Jan 1, 2021 · Conclusion: This investigation found that IGF2BP1 has a crucial role in the m 6 A-dependent regulatory mechanism for endometrial cancer. This study provides new insights into our understanding of disease progression and provides another potential route for understanding biological functions.