Immunoglobulin M (IgM) is the largest of several isotypes of antibodies (also known as immunoglobulin) that are produced by vertebrates. IgM is the first antibody to appear in the response to initial exposure to an antigen; [1] [2] causing it to …

Dec 19, 2022 · IgM immunoglobulins are produced by plasma cells as part of the body's adaptive humoral immune response against a foreign pathogen. Resting mature yet naive, B lymphocytes express IgM as a transmembrane antigen receptor that …

Jan 23, 2024 · Immunoglobulin M is the antibody formed during the initial response to an antigen or microbe. Following stimulation of antigen, IgM-producing plasma cells migrate from the lymph node to bone marrow, where they turn into long-lived plasma cells.

Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-immunoglobulins and have been highly conserved during evolution. IgMs are initially expressed during B cell ontogeny and are the first antibodies secreted following exposure to foreign antigens.

In this review, we explore how IgM structure and BCR signaling shapes B cell development, self and non-self-antigen-specific antibody responses, responses to infectious (such as viruses, parasites, and fungal) and non-communicable diseases (such …

Jun 26, 2022 · Immunoglobulin M (IgM) is an antigen receptor on B cells and the first antibody produced in an immune response. It is present both on B cells, and as a soluble molecule in the blood. Because of its large size (900 kDa), IgM is found primarily in the intravascular space i.e. in the bloodstream and also lymph fluid.

Jan 15, 2025 · IgM acts as the body’s initial defense mechanism when encountering foreign pathogens. As the first antibody isotype produced during an adaptive immune response, IgM is rapidly synthesized and secreted by B cells following antigen exposure.

Feb 6, 2020 · Immunoglobulin M (IgM) plays a pivotal role in both humoral and mucosal immunity. Its assembly and transport depend on the joining chain (J-chain) and the polymeric immunoglobulin receptor (pIgR), but the underlying molecular mechanisms of …

1 day ago · IgM is the first isotype to be produced during both phylogenesis and ontogeny [].In B-cell development, the repertoire of HCs and LCs is generated by somatic recombination of their variable antigen binding domains, which are combined with a constant region (Cμ in the case of IgM) endowed with functional properties.

Jul 19, 2024 · Immunoglobulin M (IgM) holds a pivotal role in the immune system, being one of the first antibodies produced in response to an infection. Its unique structure and functional properties make it crucial for early defense mechanisms against pathogens.