Nov 7, 2022 · Here we describe the development of a new ASGPR targeting chimera (ATAC) platform using bifunctional molecules containing Avilar’s novel, potent, small-molecule ASGPR-binding ligands. For proof-of-concept studies, ATACs were designed to target the extracellular protein IgG, a high plasma concentration and long half-life protein.

The asialoglycoprotein receptor (ASGPR) is a hepatic receptor that mediates removal of potentially hazardous glycoconjugates from blood in health and disease. The receptor comprises two proteins, asialoglycoprotein receptor 1 and 2 (ASGR1 and ASGR2), encoded by the genes ASGR1 and ASGR2. Design and Methods.

Here, we present a comprehensive biochemical, biophysical, and structural characterization of recombinantly produced monomeric, dimeric and polymeric human IgA.

We describe herein the development of a novel ASGPR-targeting chimera (ATAC) platform using bifunctional compounds containing Avilar’s novel, potent, small-molecule ASGPR-binding ligands.

The hepatic asialoglycoprotein receptor (ASGPR) was recently identified as a target antigen for both humoral and cellular immune response in inflammatory liver diseases. Thereby anti-ASGPR autoantibodies directed against human substrate were closely associated with autoimmune chronic active hepatiti …

IgG MoDEs are bifunctional molecules engineered to bind simultaneously to IgG molecules and to hepatic asialoglycoprotein (ASGPR) receptors, leading to internalization and endo-lysosomal degradation of IgG in the liver.

Nov 2, 2023 · Study Designs: SPR studies: ATAC-77 was added to recombinant human IgG1-Fc or recombinant human ASGPR. TCF studies: ATAC-77 and fluorescently-labeled human IgG were added to HepG2 cells on ice. Cell-associated fluorescence was measured by …

The asialoglycoprotein receptors (ASGPR) are lectins which bind asialoglycoprotein and glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are integral membrane proteins and are located on mammalian hepatocytes (liver cells), remove target glycoproteins from circulation. [1]

Dec 1, 2012 · Asialoglycoprotein receptor (ASGPR) has attracted the attention of liver immunologists for many years. This liver-specific lectin was found to be a major B and T cell autoantigenic target in patients with autoimmune liver diseases, and …

Sep 1, 2023 · Terminal galactose and N-Acetylgalactosamine are recognized by ASGPR, while terminal mannose, fucose, and N-Acetylglucosamine are recognized by MRC1. The effects of ASGPR and MRC1 deficiency on the N-glycosylation …