Negative control for in vivo animal model study – This IgG4/kappa isotype antibody can be used in any animal model as a antibody negative control.

Apr 24, 2023 · IgG4 is the least abundant subclass of IgG in human serum and has unique functional features. IgG4 is largely unable to activate antibody-dependent immune effector responses and, furthermore,...

The immunoglobulin light chain genes in tetrapods can be classified into three distinct groups: kappa (κ), lambda (λ), and sigma (σ). The divergence of the κ, λ, and σ isotypes preceded the radiation of tetrapods .

Feb 7, 2023 · An indolent, gradual, inflammatory (likely autoimmune) process driven largely by infiltrating T and B cells can generate a milieu for the far more exuberant expansion of the appropriate extrafollicular helper T cells that drive IgG4 …

IgG4-related disease is a fibro-inflammatory condition that can affect nearly any organ system. Common presentations include major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal fibrosis and tubulointerstitial nephritis.

Maternal IgG is transferred to the fetus through the placenta and is vital for immune defense of the neonate against infections. IgG4, κ recombinant protein is obtained by expression of a phage library in a human cell line and purified by affinity chromatography.

Kappa/lambda serum FLC in patients with IgG4-RD. Comparison of serum-free κ and λ light chains in controls, IgG4-RD patients with active disease (IgG4-RD) and nonactive disease (IgG4-RD NA). Median and interquartile ranges are shown.

Recombinant Human IgG4 kappa, AbD18705_hIgG4 is a recombinant human IgG4 antibody with a kappa light chain. AbD18705_hIgG4 is specific for green fluorescent protein (GFP) and has no known reactivity with mammalian proteins or other antigens.

IgG4 plays a role in autoimmune diseases other than rheumatic diseases, such as pemphigus, bullous pemphigoid, idiopathic membranous glomerulonephritis, or myasthenia gravis, but also in helmints infections. Research shows the importance of IgG4 in malignancy of neoplasms.

Invitrogen Anti-Human IgG4, kappa Bispecific, Catalog # MA5-55041. Tested in Flow Cytometry (Flow) applications. Supplied as 100 µg purified isotype control (0.95 mg/mL).