Understanding the molecular and functional properties of IgG3 may facilitate the development of improved Ab-based immunotherapies and vaccines against infectious diseases.

IgG is divided into four subclasses: IgG1, IgG2, IgG3, and IgG4. People are said to have an IgG subclass deficiency when they lack or have very low levels of one or two IgG subclasses, but have normal levels of other immunoglobulins.

Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 ...

Evidence suggests that the IgG3 hinge may allow targeting of antigens or epitopes less suited to ligation by other IgG types, with the potential to more effectively stimulate cellular activity via Fcɣ receptors.

IgG1 and IgG3 respond to protein antigens. They are T-dependent antigens; IgG2 and IgG4 respond to polysaccharide antigens, which are T-independent antigens. IgG functions by opsonizing microbes for phagocytosis and killing, activating the complement cascade, and neutralizing many bacterial endotoxins and viruses.

High levels of Immunoglobulin G3 (IgG3) in your blood could suggest that your body is actively fighting off an infection or disease. This is because IgG3 is a type of protein that your immune system produces to combat harmful invaders, like bacteria or viruses.

Feb 8, 2019 · IgG3 has been associated with enhanced control or protection against a range of intracellular bacteria, parasites, and viruses. IgG3 Abs are potent mediators of effector functions, including enhanced ADCC, opsonophagocytosis, complement activation, and neutralization, compared with other IgG subclasses.

Jul 7, 2023 · IgG3 forms elevated hexameric Fc platforms that extend above the protein corona to maximise binding to receptors and the complement C1 complex, which here adopts a unique protease conformation...

Jan 23, 2024 · IgG3. IgG3 comprises around 5 to 10% of total IgG and has a molecular weight of 170 kDa. They play a major role in the immune responses against protein or polypeptide antigens which are T dependent antigens. The IgG3 are particularly good opsonins and mediators of ADCC because FcγRs bind sIgG3 antibodies with high affinity.

IgG3 characteristics make IgG3 a uniquely potent immunoglobulin, with the potential for triggering effector functions including complement activation, antibody (Ab)-mediated phagocytosis, or Ab-mediated cellular cytotoxicity (ADCC). compared Recent studies underscore the importance of IgG3 effector functions against