Dec 20, 2024 · Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an atypical protein is found in the blood. The protein is called monoclonal protein or M protein. This protein is made in the soft, blood-producing tissue in the center of bones.

Jan 14, 2025 · IgM MGUS – IgM MGUS accounts for approximately 15 percent of MGUS cases. It is considered separately from the non-IgM MGUS because it has the potential to progress to smoldering Waldenström macroglobulinemia and to symptomatic Waldenström macroglobulinemia, and less often to lymphoma or AL amyloidosis.

Monoclonal gammopathies are conditions in which abnormal proteins are found in the blood. The most common condition linked with these abnormal proteins is monoclonal gammopathy of undetermined significance (MGUS). MGUS usually causes no symptoms. Diagnosis is often done with a lab test called protein electrophoresis.

Jan 11, 2018 · A bone marrow can be deferred in patients with small (<1.5 gm/dL) IgM MGUS, low-risk MGUS (IgG type, M- protein <1.5 gm/dL, normal free light-chain ratio), and small (involved/uninvolved serum-free light-chain ratio <8) light-chain MGUS in whom there are no clinical features concerning for myeloma or lymphoplasmacytic malignancy.

Dec 10, 2021 · Quantitative immunoglobulins showed normal IgG, immunoglobulin A (IgA), and immunoglobulin M (IgM) levels. Also, serum free light chains (FLCs) were evaluated, and they showed normal levels.

Jul 10, 2022 · Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic premalignant plasma cell disorder that is characterized by the presence of serum M-protein less than 30 g/L or 3 g/dL, bone marrow (BM) clonal plasma cells less than 10%, absence of plasma cell myeloma (PCM) related end-organ damage (CRAB symptoms: hypercalcemia, renal ...

Non-IgM MGUS—Also called plasma cell MGUS, this is the most common subtype. It involves IgG, IgA, IgD or IgE immunoglobulins. It may progress to myeloma or related plasma cell disorders. The type of immunoglobulin that most commonly progresses to myeloma is IgG.

There are five types of paraprotein: IgG, IgA, IgM, IgD and IgE. Ig stands for immunoglobulin, another name for paraprotein. There are two types of light chain: kappa (κ) and lambda (λ). So when you get an MGUS diagnosis, you might be told the type is IgG lambda, for example.

Jan 1, 2019 · Monoclonal gammopathy of undetermined significance (MGUS) is commonly diagnosed in outpatients being worked up for an array of clinical concerns. It carries a risk of progression to myeloma and other lymphoproliferative disorders that, albeit low (1% per year), warrants regular follow-up.

Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia in which plasma cells or other types of antibody-producing cells secrete a myeloma protein, i.e. an abnormal antibody, into the blood; this abnormal protein is usually found during standard laboratory blood or urine tests.