Dec 17, 2018 · Overexpression of IFNAR1, MX1 and signal transducer and activator of transcription 1 (Stat1) indicated the endogenous IFNα activation in tumour microenvironment, which correlated with...

STAT1 and STAT2 are the first STAT proteins identified in the IFN signal transduction pathways that have an essential role in suppressing tumor cell proliferation, differentiation, apoptosis and angiogenesis.

Oct 3, 2004 · Here we show that interferon-α (IFN-α)–induced activation of the transcriptional activator STAT1 and inflammatory STAT1 target genes was enhanced in IFN-γ-primed macrophages.

Dec 23, 2013 · Type I IFNs signal via the IFNα receptor (IFNAR) to activate receptor-associated Janus kinase 1 (JAK1) and tyrosine kinase 2 (TYK2) kinases and downstream signal transducer and activator of...

STAT1 phosphorylation is central for transduction of type I ifn-mediated antiviral response. Upon activation by IFNs, JAK1 and TYK2 are recruited to the cytoplasmic region of IFNAR1 and IFNAR2, facilitating phosphorylation of STAT1 and STAT2.

STAT1 and STAT2 proteins are key mediators of type I and type III interferon (IFN) signaling, and are essential components of the cellular antiviral response and adaptive immunity. They associate with IFN regulatory factor 9 (IRF9) to form a heterotrimeric transcription factor complex known as …

Jun 24, 2020 · A better understanding of radiation-induced IFN/STAT1 signaling will open new opportunities for the development of novel therapeutic strategies, as well as define new approaches to enhance radio-immunotherapy efficacy in …

Mar 9, 2001 · Here we demonstrate arginine methylation of STAT1 by the protein arginine methyl-transferase PRMT1 as a novel requirement for IFNα/β-induced transcription. Methyl-thioadenosine, a methyl-transferase inhibitor that accumulates in many transformed cells, inhibits STAT1-mediated IFN responses.

Nov 23, 2021 · The residual phosphorylation of STAT1 (but not of STAT2 or STAT3) observed for IFNAR2 Δ315, where only the JAK1 binding site was left in the ICD, suggests that STAT1 can be phosphorylated upon IFN-I stimulation without binding the receptor.

Jul 1, 2008 · Here, we show that both Stat1 Y701 phosphorylation and nuclear translocation are required for IFN-induced S727 phosphorylation. We further show that Stat1 mutants lacking the ability to stably associate with chromatin are poorly serine-phosphorylated in response to IFN-γ.