007900 C57BL/6- Gt(ROSA)26Sor tm1(HBEGF)Awai /J The Cre-inducible expression of DTR in these iDTR knock-in mice render cells susceptible to ablation following Diphtheria toxin administration.

May 20, 2005 · To streamline this approach, we generated Cre-inducible DTR transgenic mice (iDTR) in which Cre-mediated excision of a STOP cassette renders cells sensitive to DT.

To streamline this approach, we generated Cre-inducible DTR transgenic mice (iDTR) in which Cre-mediated excision of a STOP cassette renders cells sensitive to DT. We tested the iDTR strain by crossing to the T cell- and B cell-specific CD4-Cre and CD19-Cre strains, respectively, and observed efficient ablation of T and B cells after exposure ...

We have shown that cross of these mice, termed iDTR, to mice that express Cre in B cells (CD19-Cre) results in mice with B cells expressing DTR, and thus are made sensitive to depletion following injection with diphtheria toxin (DT).

Jan 4, 2022 · Cx3cr1-iDTR mice were generated by breeding between Cx3cr1CreERT2 mice and ROSA26iDTR mice and treated with tamoxifen 4–6 weeks ahead of Dtx treatment to specifically target microglia, but not peripheral macrophages.

To investigate the role of astrocytes in hypoxia-induced retinopathy, we utilized a 7-day systemic hypoxia model using the GFAP-Cre ERT2:Rosa26 iDTR transgenic mouse line. This allows for the induction of inflammatory reactive astrogliosis …

Aug 1, 2001 · We expressed the diphtheria toxin (DT) receptor in transgenic mice using a hepatocyte-specific promoter and found that injection of DT caused fulminant hepatitis.

The iDTR reporter mouse (JAX#007900) expresses the diphtheria toxin receptor upon cre recombination (Buch et al., 2005), allowing for the controlling the timing of M/T cell ablation after ...

Apr 30, 2021 · We generated knock-in mice, termed Mcpt5 / Cma1DTR mice, expressing human diphtheria toxin A (DT) receptor under the endogenous promoter of Mcpt5 (also known as Cma1), which encodes mouse mast cell protease-5.

IDTR mice are genetically engineered mice that express an inducible diphtheria toxin receptor (IDTR) gene. This gene allows for the targeted depletion of specific cell populations upon administration of diphtheria toxin.