Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. [5] This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors .

Mar 30, 2025 · ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. Diseases associated with ITGB1 include Gallbladder Cancer and Breast Cancer. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway.

Jan 26, 2024 · This review summarizes the biological roles of ITGB1 in benign diseases and cancers, and compiles the current status of ITGB1 function and therapy in various aspects of tumorigenesis and progression. Finally, future research directions and application prospects of ITGB1 are suggested.

Integrin β1 (ITGB1) is associated with vasculogenic mimicry (VM)‐like network formation in various cancer cell lines. A, KO of ITGB1 in MDA‐MB‐231 (left) and CHL‐1 (right) cells. Parental and ITGB1‐KO cells were cultured, and the cell lysates …

ITGB1 promotes the chondrogenic differentiation of human adipose-derived mesenchymal stem cells by activating the ERK signaling. Integrin VLA-4 as a PET imaging biomarker of hyper-adhesion in transgenic sickle mice.

ITGB1, 4, and 7 and ITGB1, 3, 5, 6, and 8 were found as prognostic markers in LUAD and LUSC, respectively. ITGBs were significantly associated with immune cell infiltration and the expression of immunomodulation-related genes.

Feb 8, 2025 · A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of integrin, beta 1 (ITGB1, fibronectin receptor, CD29) expression by HIV-1 Vpr in Vpr transduced macrophages

Explore the ITGB1 gene, also known as Integrin Beta 1, its role in cell adhesion, signaling, and its implications in cancer and other diseases. Discover research, clinical significance, and therapeutic potential.

Dec 1, 2022 · Integrin beta1 (ITGB1) is widely expressed in epithelial cells and promotes cell adhesion and growth. Its impact on tumor progression was described for different tumor entities before, data on...

Integrinβ-1 (ITGB1) is a crucial member of the transmembrane glycoprotein signaling receptor family and is also central to the integrin family. It forms heterodimers with other ligands, participates in intracellular signaling and controls a variety ...