Jul 22, 2024 · The interferon-stimulated gene 15 (ISG15) level was upregulated in the kidneys of mice injured by ischemia-reperfusion injury (IRI), cisplatin, or unilateral ureteral obstruction …

Mar 26, 2024 · To clarify the function of ISG15 in antiviral immunity, we obtained an ISG15 KO (Isg15 −/−) mouse from the Jackson Laboratory (Figure S7A). Genotype and western blot …

敲除Isg15基因exon 2，建立Isg15基因敲除小鼠模型。 *使用本品系发表的文献需注明: Isg15-KO mice (Cat. NO. NM-KO-2107651) were purchased from Shanghai Model Organisms Center, Inc..

Oct 4, 2019 · ISG-encoded proteins, including ISG15, are critical orchestrators of the host cell defense arsenal to viral infection. The role of ISG15 in antiviral immunity has been investigated …

Mar 16, 2021 · Our work demonstrates a crucial role for ISG15 in the MDA5-mediated antiviral response, and also identifies a key immune evasion mechanism of SARS-CoV-2, which may …

Isg15 KO decreased TGF R1 and p-Smad2 levels in the kidneys of UIRI, UUO, cisplatin treated mice. (A-C) Western blots of TGF R1, p-Smad2, -actin in the kidney of WT

Strain Name: C57BL/6JGpt-Isg15 em4Cd1539 /GptStrain Number: T012680: Official Symbol: Isg15: Strain Strategy: T012680.Isg15 Cas9-KO Strategy-EN.pdf: Official Full Name: ISG15 …

You can quickly query the required genetically engineered global knockout (KO) mouse, conditional knockout (cKO/floxed) mouse and microRNA KO mouse strains by simply entering …

Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. [5] [6] ISG15 is induced by type I interferon (IFN) and serves many functions, …

Feb 16, 2024 · ISG15 is a type I interferon-induced ubiquitin-like modifier that functions in innate immune responses. The major human ISG15 ligase is hHERC5, a ribosome-associated HECT …