In this review, we focus primarily on the upregulated, IFN-stimulated genes (ISGs). We describe ISGs that positively and negatively regulate type I and III IFN signaling along with those that …

While the OAS/RNase L pathway globally degrades RNA and arrests translation, ISG20 and ZAP employ targeted RNA degradation and translation inhibition to block viral replication. …

ISG15 is part of a ubiquitin-like pathway that modulates the function of numerous protein targets. The Mx proteins seem to survey exocytic events and mediate vesicle trafficking to trap viral...

Many viruses trigger the type I interferon (IFN) system, leading to the transcription of hundreds of interferon-stimulated genes (ISGs). The products of these ISGs exert numerous antiviral …

Apr 14, 2022 · The oligoadenylate synthetase (OAS) family of ISGs are key enzymes involved in antiviral defense . Upon sensing cytosolic dsRNA, OAS proteins are activated to catalyze the …

Feb 3, 2022 · OAS encodes IFN-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral responses 52,53.

Aug 13, 2024 · One ISG that inhibits protein translation by nucleic acid degradation is oligoadenylate synthetase 1 (OAS1). Canonically, OAS1 senses intracellular double-stranded …

Sep 28, 2021 · We used arrayed ISG expression screening to reveal that 2′-5′-oligoadenylate synthetase 1 (OAS1) consistently inhibited SARS-CoV-2 in different contexts. Using CRISPR …

Jun 1, 2015 · We have recently described the mechanism of antiviral activity of one such ISG, Oligoadenylate Synthetase-Like (OASL) [16••]. Here we discuss some of the unique features …

While the OAS/RNase L pathway globally degrades RNA and arrests translation, ISG20 and ZAP employ targeted RNA degradation and translation inhibition to block viral replication. …