Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor that produced IFN-I and regulated innate immune response, subsequent studies have revealed that IRF7 performs a multifaceted and versatile functions in multiple biological processes.

Our study demonstrated that STAT1-IRF7-MHC I complex axis were crucial for IFN-α signalling in islets, and created positive feedback through IRF7-STAT2 cascade amplifying signals which accelerated the process of T1D.

Oct 9, 2024 · The C-terminal region of IRF7 contains multiple regulatory domains for its activation. 37 IRF7, sharing a close relationship with IRF3, operates as a transcription factor that requires...

Aug 13, 2021 · Interferon regulatory factor 7 (IRF7) has been identified as a significant regulator in corneal endothelial cells after an HSV-1 infection. To examine the role played by IRF7, the DNA binding domain (DBD) of IRF7 of human corneal endothelial cells (HCEn) was disrupted.

Apr 14, 2011 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I...

Our study demonstrated that STAT1-IRF7-MHC I complex axis were crucial for IFN-α signalling in islets, and created positive feedback through IRF7-STAT2 cascade amplifying signals which accelerated the process of T1D.

Dec 16, 2022 · In addition, a study by Hemin et al. demonstrated that STAT1-IRF7-MHC I complex axis was crucial for IFN-α signaling in islets and created positive feedback through IRF7-STAT2 cascade amplifying signals which accelerated the process of type 1 diabetes.

Our results showed that DNA vaccine induced, Irf7-dependent signaling, as part of the Sting pathway, was critical for generation of both innate cytokine signaling and antigen-specific B and T cell responses.

Feb 8, 2025 · Interferon-alpha promotes MHC I antigen presentation of islet beta cells through STAT1-IRF7 pathway in type 1 diabetes. Loss of IRF7 accelerates acute myeloid leukemia progression and induces VCAM1-VLA-4 mediated intracerebral invasion.

Aug 13, 2021 · Interferon regulatory factor 7 (IRF7) has been identified as a significant regulator in corneal endothelial cells after an HSV-1 infection. To examine the role played by IRF7, the DNA...