IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes , including the type I interferon genes.

Mar 30, 2025 · IRF7 (Interferon Regulatory Factor 7) is a Protein Coding gene. Diseases associated with IRF7 include Immunodeficiency 39 and Primary Immunodeficiency With Predisposition To Severe Viral Infection. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and SARS-CoV-2 Infection.

Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs) family, is located downstream of the pattern recognition receptors (PRRs)-mediated signaling pathway and is essential for the production of type I interferon (IFN-I).

Aug 9, 2023 · Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor that produced IFN-I and regulated innate immune response, subsequent studies have revealed that IRF7 performs a multifaceted and versatile functions in …

Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I...

May 4, 2015 · Using Irf7-null mice, they showed that the transcription factor IRF7 is essential for the induction of IFN-alpha/beta genes via the virus-activated, MYD88 (602170)-independent pathway and the toll-like receptor (TLR)-activated, MYD88-dependent pathway.

Feb 8, 2025 · How IRF7 promotes autoimmune B cell responses and systemic autoimmunity is unclear. Analysis of spontaneous SLE-prone mice deficient in IRF7 uncovered the IRF7 role in regulating autoimmune germinal center (GC), plasma …

Learn about the IRF7 gene, its function in immunity and inflammation, and its role in antiviral response, cancer, and autoimmunity. Explore IRF7 signaling, regulation, and research.

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes.

Interferon regulatory factors (IRFs) are transcriptional regulators of type I IFN and IFN-inducible genes. Furthermore, IRF7 gene polymorphisms are associated with SSc susceptibility. In our most recent global gene expression study, IRF7 was the most prominent transcription factor in SSc skin (manuscript in press).