Ironman training for NK cells - Nature Immunology
Sep 11, 2023 · A new study finds that IRF4 is upregulated following natural killer (NK) cell activation and is required for the differentiation and expansion of virus-specific NK cells by …
Feed-forward regulatory loop driven by IRF4 and NF-κB in …
Mar 19, 2020 · IRF4 and NF-κB form a feed-forward loop in ATL cells to coordinately regulate gene expressions. IRF4 and NF-κB bindings are enriched in super-enhancers and regulate …
Specificity through cooperation: BATF–IRF interactions ... - Nature
Jun 21, 2013 · BATF leucine zipper motifs interact with interferon-regulatory factor 4 (IRF4) and IRF8 at AP-1–IRF consensus elements (AICEs). The discovery of the BATF–IRF interaction …
BATF and IRF4 cooperate to counter exhaustion in tumor ... - Nature
Jul 19, 2021 · Here, we show that basic leucine zipper ATF-like transcription factor (BATF) and interferon regulatory factor 4 (IRF4) cooperate to counter T cell exhaustion in mouse tumor …
Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require ...
Sep 7, 2012 · With the importance of IRF4 for Th17-cell differentiation on one hand, and the differences in the regulation of IL-17 production between αβ T cells and γδ T cells on the …
IRF4 - Wikipedia
Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene. [5][6][7] IRF4 functions as a key regulatory transcription factor in the …
Regulatory effects of IRF4 on immune cells in the tumor ...
IRF4 is essential for the sustained differentiation and proliferation of CD8+ cytotoxic T cells (CTLs) and T helper 1 (Th1) cells, promoting anti-tumor immunity. In parallel, IRF4 is also …
Chapter 8 Natural Killer T (NKT) Cells in Mice and Men
Natural killer T (NKT) cells are innate natural killer (NK)-like cells that express a limited repertoire of T cell receptors (TCRs). Akin to other innate cells, NKT cells acquire functional …
IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT …
Dec 24, 2024 · Here, we use a multi-omics approach to study the immune-epithelial crosstalk and identify CD1d-restricted natural killer T (NKT) cells as key regulators of IEC biology. We find …
IRF4 protein (human) - STRING interaction network - string-db.org
Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in …