Mar 30, 2025 · IRF4 (Interferon Regulatory Factor 4) is a Protein Coding gene. Diseases associated with IRF4 include Skin/Hair/Eye Pigmentation, Variation In, 8 and Immunodeficiency 131. Among its related pathways are MITF-M-dependent gene expression and Signaling by ALK in …

Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene. [5] [6] [7] IRF4 functions as a key regulatory transcription factor in the development of human immune cells. [8] [9] The expression of IRF4 is essential for the differentiation of T lymphocytes and B lymphocytes as well as certain ...

Feb 19, 2025 · Title: Interferon-induced protein 44 (IFI44) and interferon regulatory factor 4 (IRF4) gene expression in rheumatoid arthritis. IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression.

The interferon regulatory factor 4 (IRF4) gene belongs to a family of DNA-binding proteins that play an important role in immune system development and function [1]. IRF4 polymorphisms have been independently associated with pigmentation and age-specific effects on melanocytic naevus count in European-derived populations [2,3].

Interferon-induced protein 44 (IFI44) and interferon regulatory factor 4 (IRF4) gene expression in rheumatoid arthritis. IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression. Clinical boundaries in adult cases of …

Sep 2, 2022 · IRF4 induces several oncogenes, such as MYC, as well as genes that characterize each cell type by utilizing its ability as a master regulator of immunity.

Showing 25 of 51,245 results for IRF4 Search Time: 0 ms in Aliases & Descriptions Drugs & Compounds Disorders Text-Mined Disorders Domains Expression in Human Tissues Function Genomics Localization Orthologs Paralogs Pathways Phenotypes Proteins Publications Summaries Transcripts Variants in category Protein Coding RNA Gene Functional Element ...

Nov 13, 2024 · IRF4 interferon regulatory factor 4 Gene ID: 3662, updated on 13-Nov-2024 Gene type: protein coding Also known as: MUM1; LSIRF; SHEP8; NF-EM5. See all available tests in GTR for this gene; Go to complete Gene record for IRF4; Go to Variation Viewer for IRF4 variants; Summary

Gene expression profiling and genomewide chromatin immunoprecipitation analysis uncovered an extensive network of IRF4 target genes and identified MYC (190080) as a direct target of IRF4 in activated B cells and myeloma. Unexpectedly, IRF4 was itself a direct target of MYC transactivation, generating an autoregulatory circuit in myeloma cells.

Feb 1, 2014 · IRF4 is obligatory required for the terminal differetiation of mature B cells to plasma cells and has been shown to play a central role in the pathogenesis of MM. IRF4 is recurrently translocated and juxtaposed to the IgH promoter t(6;14)(p25;q32) in a significant proportion (~21%) of MM cases.