IRF4 is an essential regulatory component at various stages of B cell development. In early B cell development, IRF4 functions alongside IRF8 to induce the expression of the Ikaros and Aiolos transcription factors, which decrease expression of the pre-B-cell-receptor. [9]

Interferon regulatory factor 4 (IRF4) regulates key points from pre-B cell development and receptor editing to germinal center formation, class-switch recombination and plasma cell differentiation.

Oct 9, 2024 · This review explores the diverse functions of nine mammalian IRF members, each featuring conserved domains essential for interactions with other transcription factors and cofactors.

Interferon Regulatory Factor 4 (IRF4) and IRF8 are critical regulators of immune system development and function. In B lymphocytes, IRF4 and IRF8 have been shown to control important events during their development and maturation including pre-B ...

We first outline the complex role of IRF4 in the function of CD4 + T cells and then discuss recent studies from our laboratory that have revealed a surprising role for components of Rho guanosine triphosphatase-mediated pathways in controlling the activity of IRF4.

IRF-4 is a transcription factor belonging to the interferon regulatory factor family, primarily expressed in lymphoid cells. It plays a crucial role in the regulation of gene expression in B cells, particularly in enhancing the expression of Ig light chain genes upon B cell activation.

Mar 30, 2025 · IRF4 (Interferon Regulatory Factor 4) is a Protein Coding gene. Diseases associated with IRF4 include Skin/Hair/Eye Pigmentation, Variation In, 8 and Immunodeficiency 131. Among its related pathways are MITF-M-dependent gene expression and Signaling by ALK in …

Nov 9, 2016 · IRF4 is a hematopoietic-specific transcription factor critical for lymphoid and myeloid lineage development and function, and its expression is thus restricted to immune cells such as T cells, B cells, macrophages, and dendritic cells (DCs). Herein, we summarize the specific roles of IRF4 in immune cell development.

Interferon-induced protein 44 (IFI44) and interferon regulatory factor 4 (IRF4) gene expression in rheumatoid arthritis. IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression. Clinical boundaries in adult cases of …

In this review, the roles of IRF4 in the immune response are briefly summarized and discussed, with particular focus on its essential and distinct functions in immune cell development. Keywords: Dendritic cells (DCs); Interferon regulatory factor 4 (IRF4); Lymphoid cells; Macrophages; Myeloid cells; Myeloid-derived suppressor cells (MDSCs).