Among myeloid cells, IRF4 expression has been identified in dendritic cells (DCs) and macrophages. [8][9] The transcription factors IRF4 and IRF8 work in concert to achieve DC differentiation. [8][9] IRF4 expression is responsible for inducing development of CD4+ DCs, while IRF8 expression is necessary for the development of CD8+ DCs. [9] .

IRF4 regulates the migration of DCs in the skin as well as the differentiation of specialized DC subsets, which can promote either T H 17 or T H 2 responses [22 – 26].

Herein we demonstrate that Th2-promoting stimuli induce DC expression of IRF4. Mice with conditional deletion of Irf4 in DCs show a dramatic defect in Th2-type lung inflammation, yet retain the ability to elicit pulmonary Th1 anti-viral responses.

IRF4 is a key regulator of several steps of lymphoid, myeloid and dendritic cell (DC) differentiation. Particular attention has recently been dedicated to the role of IRF4 in B-cell differentiation and function. 72 The functions of IRF4 in oncogenesis and tumor progression, in particular in relationship to hematopoietic malignancies, has been ...

Nov 6, 2015 · Although autoimmunity in DKO mice is accompanied by dysregulated IRF4 activity in both T and B cells, SWAP-70 is also known to regulate multiple aspects of DC biology leading us to directly evaluate DC development and function in these mice.

Nov 6, 2020 · All pathogens are taken up by a population of IRF4+ dermal migratory dendritic cells (migDC2) that similarly upregulate surface co-stimulatory molecules but express pathogen-specific...

Dec 12, 2012 · Our data revealed heterogeneity in the mouse CD11b + DC compartment and identifed mucosal tissues IRF4-expressing DCs specialized in instructing IL-17 responses in both mouse and human.

Nov 9, 2016 · IRF4 is a hematopoietic-specific transcription factor critical for lymphoid and myeloid lineage development and function, and its expression is thus restricted to immune cells such as T cells, B cells, macrophages, and dendritic cells (DCs). Herein, we summarize the specific roles of IRF4 in immune cell development.

Feb 15, 2016 · Using mice in which a conditional Irf4 or Irf8 allele is deleted in CD11c (+) cells, we determined whether IRF4 or IRF8 deficiency beginning in CD11c (+) cDC precursors (pre-cDCs) changed the homeostasis of mature DCs or pre-DCs in the lung, dermis, and spleen.

Sep 3, 2021 · IRF4 and IRF8 are highly homologous and have both redundant and unique roles in DC development and function. Irf4 is expressed at a higher level in cDC2s than in cDC1s.