Jul 3, 2014 · Here, we show that IRF4 is transcriptionally regulated by cold and cAMP in murine and human BAT prior to the induction of Ucp1 and that mice that overexpress IRF4 transgenically in BAT display enhanced thermogenic gene expression, energy expenditure, and cold tolerance.

Jul 19, 2021 · Here, we show that basic leucine zipper ATF-like transcription factor (BATF) and interferon regulatory factor 4 (IRF4) cooperate to counter T cell exhaustion in mouse tumor models.

Oct 2, 2018 · Loss of IRF4 induces myogenic gene expression in BAT, including the secreted factor myostatin, a known inhibitor of muscle function. Reducing myostatin via neutralizing antibodies or soluble receptor rescues the exercise capacity of BATI4KO mice.

Sep 19, 2012 · The pleiotropic transcription factor IRF4 is shown to regulate CD4+ T-cell differentiation and TH17 function through cooperative binding interactions with BATF and JUN family proteins via AP1...

Oct 2, 2018 · Loss of IRF4 induces myogenic gene expression in BAT, including the secreted factor myostatin, a known inhibitor of muscle function. Reducing myostatin via neutralizing antibodies or soluble receptor rescues the exercise capacity of BATI4KO mice.

Jun 21, 2013 · BATF leucine zipper motifs interact with interferon-regulatory factor 4 (IRF4) and IRF8 at AP-1–IRF consensus elements (AICEs). The discovery of the BATF–IRF interaction adds additional...

Expression of the transcription factor BATF reduced exhaustion of CAR T cells and sustained tumor inhibition.

Here, we find that loss of the transcription factor IRF4 in BAT (BATI4KO) re-duces exercise capacity, mitochondrial function, ri-bosomal protein synthesis, and mTOR signaling in muscle and causes tubular aggregate formation.

Here we show that IRF4 is transcriptionally regulated by cold and cAMP in murine and human BAT prior to the induction of Ucp1, and that mice that overexpress IRF4 transgenically in BAT display enhanced thermogenic gene expression, energy expenditure, and cold tolerance.

Jul 21, 2021 · Here, we show that basic leucine zipper ATF-like transcription factor (BATF) and interferon regulatory factor 4 (IRF4) cooperate to counter T cell exhaustion in mouse tumor models.