Dissociative TXNIP could directly interact with cytoplasmic NLRP3 and form inflammasome, eventually triggering cardiomyocyte injury. Collectively, our findings disclose that STING deficiency could alleviate LPS-induced SIC in mice.

Oct 1, 2022 · NLRP3 activation is upstream of Tau pathology, and NLRP3 activation induces Tau hyperphosphorylation and aggregation. Mn exposure-induced neurotoxicity may be associated with excessive activation of the cGAS-STING signaling pathway, leading to inflammation.

First, STING recruits NLRP3 and facilitates NLRP3 localization in the endoplasmic reticulum, thereby facilitating the inflammasome formation. Second, STING interacts with NLRP3 and attenuates K48- and K63-linked polyubiquitination of NLRP3, thereby promoting the inflammasome activation.

WDR5/DOT1L-mediated histone methylation enhances interferon regulatory transcription factor 3 (IRF3) binding to the Nlrp3 promoter and promotes STING-induced Nlrp3 transcription in hepatocytes. Moreover, hepatocyte-specific Nlrp3 deletion and downstream Gasdermin D (Gsdmd) knockout attenuate hepatic pyroptosis, inflammation, and fibrosis.

Nov 15, 2023 · The nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) is an intracellular sensor that can detect a wide range of microbial irritants, endogenous danger signals, and environmental stimuli, leading to the formation and activation of the NLRP3 inflammasome. 23 The assembly of the NLRP3 inflammasome ...

In this study, NiCl 2 upregulated the mRNA and protein levels of IL-1β via NF-κB, MAPKs and IRF3 signaling pathways, and enhanced the maturation and production of IL-1β through NLRP3 inflammasome induction.

STING/TBK1/IRF3/NF-κB/NLRP3 is a key pathway governing pyroptosis, oxidative stress and inflammation of HGFs induced by LPS.

Feb 13, 2025 · Emerging evidence suggests that NLRP3 inflammasome activation and NLRP3-induced pyroptosis play pivotal roles in the pathogenesis of sepsis and SIMI, and previous studies have revealed that NLRP3 inflammasome and pyroptosis antagonism reduce sepsis and SIMI in vitro and in vivo.

Our findings demonstrated that STING-IRF3 could trigger LPS-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3 in mice. STING knockout could suppress the phosphorylation and nuclear translocation of IRF3, which further inhibited NLRP3-mediated inflammation, apoptosis and pyroptosis of cardiomyocytes.

5 days ago · Activation of the STING signalling pathway promotes the activation of the NLRP3 inflammasome. (A and B) Stimulating bone marrow-derived macrophages (BMDMs) with MLE-12 cells supernatants as conditioned media. Western blot analysis of cGAS, STING, P-TBK1, TBK1, P-IRF3, IRF3, NLRP3 and β-actin in BMDMs (A).