NF-κB and IRF pathways: cross-regulation on target genes …
Apr 17, 2015 · IRF3 gene promoter shows a moderate response to NF-κB in 4 out of 10 cases, located in the region (0b, 500b) upstream of TSS. Strong peak for IRF1 is located in the same region as the signal for NF-κB binding, overlapping the region of weak signal for IRF3.
IRF3 inhibits nuclear translocation of NF-κB to prevent viral ... - PNAS
Using cellular and mouse models, we reveal IRF3, a critical component of innate antiviral immunity, inhibits the activity of NF-κB, the pro-inflammatory transcription factor. Mechanistically, IRF3 binds the NF-κB–p65 subunit and prevents its translocation to the nucleus.
IRF3 inhibits nuclear translocation of NF-κB to prevent viral ...
Sep 13, 2022 · Both transcriptional and apoptotic functions of IRF3 contribute to its antiviral effect. Here, we report a nontranscriptional function of IRF3, namely, the repression of IRF3-mediated NF-κB activity (RIKA), which attenuated viral activation of …
Downstream STING pathways IRF3 and NF-κB differentially
Nov 21, 2023 · Surprisingly, we found that CCL22 upregulation by dsDNA was mediated primarily by interferon regulatory factor 3 (IRF3), a key transcription factor that activates type I interferons.
TBK1 recruitment to STING activates both IRF3 and NF-κB that ... - PubMed
Apr 6, 2021 · The induction of type I interferons through the transcription factor interferon regulatory factor 3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) activation that drives immune responses against DNA viruses and tumors.
TBK1 recruitment to STING activates both IRF3 and NF-κB that ... - PNAS
The NF-κB pathway is a strong candidate for the IFN-independent STING-induced antiviral responses. We showed that NF-κB–driven genes such as CXCL1, CXCL2, and 4-1BBL are up-regulated in STING-S365A cells that may contribute to viral resistance .
The IKK Complex, a Central Regulator of NF-κB Activation
The IRF3/IRF7 pathway of the innate response to virus infection relies on two IKK-related kinases (TBK1 and IKKε), which phosphorylate the IRF3 and IRF7 transcription factors and allow their nuclear translocation and subsequent activation of their target genes.
Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB ...
Feb 5, 2018 · Poly (I:C) activates both IRF3 and NF-κB, a requirement for induction of IFNβ expression. Autocrine IFNβ initiates a JAK/STAT-mediated positive-feedback stabilising nuclear IRF3 and NF-κB...
Both transcriptional and apoptotic functions of IRF3 contribute to its antiviral effect. Here, we report a nontranscriptional function of IRF3, namely, the repression of IRF3-mediated NF- κB activity (RIKA), which attenuated viral activation of NF- …
Crosstalk in NF-κB signaling pathways - Nature Immunology
Jul 19, 2011 · In this review we briefly introduce these important NF-κB signaling nodes and focus on molecular events that allow for both integration and communication with non-NF-κB signaling pathways.