In this study, we showed that knockout of interferon regulatory factor 1 (IRF-1) in mice strongly attenuated the generation of NETs and reactive oxygen species (ROS) production in …

Our data suggest that IRF‐1 is inessential for differentiation but upregulates p47phox expression for mature‐cell ROS production. Keywords: differentiation, HL‐60 cells, inducible oxidative …

Jun 15, 2007 · Collectively, these findings demonstrate that TNF-alpha/IFN-gamma synergistically potentiates iNOS/NO induction, ROS production, and loss of DeltaPsim via STAT1 …

CONCLUSIONS: IRF-1 engages in LPS induced ROS production and mitochondrial damage in macrophages. CLINICAL IMPLICATIONS: As ROS production and mitochondrial damage play …

Dec 6, 2024 · Silencing IRF-1 Expression Enhanced ROS Accumulation and Intrinsic Apoptosis of HAEC caused by oxLDL Stimulation. Exposure of HAEC to oxLDL is an established in vitro …

In vivo, peritoneal macrophages obtained from IRF-1 KO mice demonstrate significantly decreased ROS production, mitochondrial depolarization and mitochondrial structure damage. …

ROS affects Irf-1-dependent cyclin E/CDK2 expression and cell cycle regulation under high glucose conditions

Jun 15, 2007 · This study also demonstrates that STAT1/IRF-1 plays a critical role in inducing iNOS/NO as well as ROS production and loss of ΔΨm induced by TNF-α/IFN-γ. Our results …

Feb 1, 2019 · In this study, we showed that knockout of interferon regulatory factor 1 (IRF-1) in mice strongly attenuated the generation of NETs and reactive oxygen species (ROS) …

In vitro, LPS was found to promote IRF-1 activation, reactive oxygen species (ROS) production, adenosine triphosphate (ATP) depletion, superoxide dismutase (SOD) consumption, …