3 days ago · Monoclonal Antibody for studying IRF-1. Validated for C&R, F, IF, IHC, IHC, IP, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, IRF-1 (D5E4) XP® Rabbit Monoclonal Antibody (CST #8478) is ready to ship.

IRF-1 regulates expression of target genes by binding to an interferon stimulated response element (ISRE) in their promoters. The IRF-1 protein binds to the ISRE via an N-terminal helix-turn-helix DNA binding domain, [7] which is highly conserved among all IRF proteins.

Interferon regulatory factor 1 (IRF-1) is a transcription factor activated by the JAK/STAT signaling pathway and activates numerous downstream genes . Moreover IRF-1 inhibits antitumor immunity by upregulating PD-L1 expression .

Apr 1, 2020 · Interferon regulatory factor-1 (IRF-1) is a transcription factor marked by functional diversity. IRF-1 plays a crucial role in antiviral responses and autoimmunity and in the regulation of immune system development, differentiation, and function.

Here, we report that the transcription factor interferon regulatory factor 1 (IRF1) plays critical roles in microglial activation and retinal inflammation by regulating pro- and anti-inflammatory gene expression. IRF1 expression was upregulated in activated retinal microglia compared to those at the steady state.

Jul 8, 2019 · IRF1 expression is associated with the expression of IFNβ, which leads to the activation of the JAK-STAT pathway. Blocking the JAK-STAT pathway with the Janus kinase inhibitor (JAKinib)...

Jan 21, 2021 · In 1988, IFN-regulatory factor 1 (IRF1), the first member of the IRF family to be recognized, was identified by the Taniguchi laboratory in crude nuclear extracts of Newcastle disease virus (NDV)-infected mouse L929 cells using DNA affinity column chromatography [3].

The role of IRF-1-mediated endothelial cell pyroptosis in diabetic model mice BKS-db/db was verified by in vivo assays of immunofluorescence, immunohistochemistry (IHC), hematoxylin and eosin (H&E) staining, and Masson staining.

May 28, 2021 · Interferon regulatory factor 1 (IRF-1) is a tumor suppressor gene in cancer biology with anti-proliferative and pro-apoptotic effect on cancer cells, however mechanisms of IRF-1 regulating tumor microenvironment (TME) in hepatocellular carcinoma (HCC) remain only …

Oct 24, 2020 · Discovering the signaling pathways regulating PD-L1 might help to improve ICB response rates. Here, we investigate transcription factors IRF-1 and IRF-2 signaling pathways regulating PD-L1 in HCC cells.