IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. IRAK4 contains domain structures which are similar to those of IRAK1, IRAK2, IRAK3 and Pelle.

IRAK4 signaling is a determinant of chemoresistance and disease progression in pancreatic and colorectal cancer [105, 106], and IRAK4 expression is proposed to be a biomarker and predictor of poor prognosis in IDH wild-type and 1p19p nonco-deletion gliomas [107].

Jun 13, 2019 · Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and innate immune responses.

Mar 30, 2025 · This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease.

In summary, our results indicate that IRAK4 has a critical scaffold function in myddosome formation and that its kinase activity is dispensable for myddosome assembly and activation of the NF-κB and MAPK pathways but is essential for MyD88-dependent production of …

Feb 8, 2025 · This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease.

Dec 1, 2024 · Interleukin-1 receptor-related kinase (IRAK4) is a widely expressed serine/threonine kinase involved in the regulation of innate immunity. IRAK4 plays a pivotal role as a key kinase within the downstream signaling pathway cascades of interleukin-1 receptors (IL-1R) and Toll-like receptors (TLRs).

Feb 17, 2025 · IRAK4 is a key kinase of the IL-1R/TLRs signaling pathway, targeting IRAK4 has emerged as a promising therapeutic strategy. Structurally diverse IRAK4 inhibitors or degraders have been designed and developed.

The IRAK4 gene provides instructions for making a protein that plays an important role in innate immunity, which is the body's early, nonspecific response to foreign invaders (pathogens). Learn about this gene and related health conditions.

Mar 1, 2025 · The IRAK4 inhibitor (IRAK4i) BI1543673 potently attenuates TLR4 or TLR7/8-mediated neutrophil infiltration and release of the inflammatory cytokines tumor necrosis factor-α (TNF-α), IL-1β, granulocyte-macrophage colony stimulating factor (GM-CSF), IL-8, and IL-6 in mice and human lung explants.