Cholangiocytes are the epithelial cells that line bile ducts, and ductal plate malformation is a developmental anomaly of bile ducts that causes severe congenital biliary disorders.

Human induced pluripotent stem cells (iPSCs) can give rise to multiple cell types and hold great promise in regenerative medicine and disease-modeling applications. We have developed a reliable two-step protocol to generate human mammary-like organoids from iPSCs.

Jul 8, 2021 · Here we report the single-cell characterization of the differentiation of pancreatic duct-like organoids (PDLOs) from human induced pluripotent stem cells (hiPSCs) on a microwell chip that...

Patient-derived diabetic iPSC-β cells allow for disease progression studies of pancreatic and EPs during stages 4 and 5 of differentiation, benefiting many groups studying diabetes from patient stem cells due to the unknown presence and progression of …

Nov 18, 2021 · Here, we discuss induced pluripotent stem cell (iPSC)-based models as a promising tool to model PDAC development and treatment responses. Aside from their use as models, they also hold great potential for novel immunotherapies.

Apr 26, 2024 · In this review, we outline key developments in the iPSC field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic applications.

Nov 28, 2023 · In this study, we combined three culture technologies to generate a PDAC organoid that contained 3D epithelial structures and heterogeneous stromal cells without extrinsic ECM.

Apr 2, 2025 · Stem cell–derived pancreatic islets are being investigated as a possible therapy for type 1 diabetes. Such β cell replacement therapies would require large numbers of stem cell–derived endocrine cells produced according to clinical standard manufacturing practices.

Jun 27, 2013 · Highlights • An iPSC-like line was created from human pancreatic ductal adenocarcinoma (PDAC) • Teratomas from PDAC iPSC-like cells undergo early to invasive stages of human cancer • Stages of human pancreatic cancer can be studied in live iPSC teratomas and explants •

Direct reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) provides an invaluable resource for regenerative medicine, enabling the generation of patient-specific cells of any lineage without the use of embryonic material.