Jun 1, 2022 · SMARCB1 (SWI / SNF related, matrix associated, actin dependent regulator of chromatin subfamily B member 1), INI1 (integrase interactor 1), BAF47, hSNF5

SMARCB1/INI1 is one of the core subunit proteins of the ATP‐dependent SWI/SNF chromatin remodeling complex, and is identified as a potent and bona fide tumor suppressor.

Jun 30, 2020 · The SMARCB1/INI1 gene was first discovered in the mid-1990s, and since then it has been revealed that loss of function mutations in this gene result in aggressive rhabdoid tumors. Recently, the term “rhabdoid tumor” has become synonymous with decreased SMARCB1/INI1 expression.

SWI/SNF -related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene. [5][6][7] The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively.

Mutations, deletions, and other somatic alterations in the tumor suppressor gene INI1 (hSNF5; SMARCB1), which encodes a subunit of the SWI/SNF chromatin remodeling complex, were first described in the malignant rhabdoid tumor of infancy.

Integrase interactor 1 (INI1) is a member of the SWI/SNF (SWItch/sucrose non-fermentable) chromatin remodeling complex, which play an important role in regulation of transcription by modulating access of protein to DNA. Loss of function of these complexes has been implicated in human cancers.

We describe here the phenotype, genotype and clinical features of a rare thyroid INI1-deficient thyroid carcinoma, discuss its nosologic and histogenetic challenges, and survey INI1 protein expression in benign and malignant thyroid lesions.

INI-1 (integrase interactor 1) is a tumor suppressor gene [1] that is constitutively expressed in most normal cells in the body. It is mutated resulting in loss of expression in malignant rhabdoid tumors and epithelioid sarcomas. INI-1 is a nuclear antigen that is normally expressed in essentially all nucleated cells.

The gene variously known as hSNF/INI1/SMARCB1/BAF47 is a putative tumour suppressor gene located on chromosome 22q11.2. It is a member of the SWI/SWF chromatin-remodelling complex and is normally expressed in all tissues.

Oct 13, 2022 · INI-1, also known as SMARCB1, is one of the core subunit proteins of the ATP-dependent SWI/SNF chromatin remodeling complex. It is involved in chromatin remodeling and transcriptional regulation and functions as a tumor suppressor.