The interleukin 4 receptor is a type I cytokine receptor. It is a heterodimer, that is, composed of two subunits. IL4R is the human gene coding for IL-4Rα, the subunit which combines with …

Mar 30, 2025 · IL4R (Interleukin 4 Receptor) is a Protein Coding gene. Diseases associated with IL4R include Ige Responsiveness, Atopic and Human Immunodeficiency Virus Type 1. Among …

We sought to provide a comprehensive analysis of the redundant and distinct roles of IL-4 and IL-13 in type 2 inflammation and report dupilumab mechanisms of action. Methods: Using …

Interleukin 4 (IL-4) was first identified as a factor that was produced by T cells and could enhance the proliferative response of B cells to anti-IgM and also was capable of inducible …

Feb 8, 2025 · Title: IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.

Mar 6, 2020 · Interleukin (IL)-4 and IL-13 are well known for their key roles in type 2 immune responses, which result in resistance to helminth parasites and inactivation of toxins.

Here we describe our current understanding of the organization of the IL-4 receptor, of the signaling pathways that are induced as a result of receptor occupancy, and of the various …

Feb 8, 2025 · Clinical resource with information about IL4R, A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci., A …

IL-4 signals through both the type I receptor composed of the IL-4Rα and common gamma chain (γC), and the type II receptor composed of the IL-4Rα and IL-13Rα1. IL-4 binds IL-4Rα in a …

Dec 1, 2016 · Interleukin-4 is the prime anti-inflammatory cytokine involved in cell proliferation, gene expression and apoptosis. α chain of IL-4R is also a fundamental part of IL-13R hence, …