IL-1RA is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R), the same receptor that binds interleukin 1 family (IL-1), preventing IL-1's from sending a signal to that cell. IL-1RA is a member of the interleukin 1 cytokine family.

Mar 30, 2025 · IL1RN (Interleukin 1 Receptor Antagonist) is a Protein Coding gene. Diseases associated with IL1RN include Chronic Recurrent Multifocal Osteomyelitis 2, With Periostitis And Pustulosis and Microvascular Complications Of Diabetes 4. Among its related pathways are Interleukin-1 family signaling and IL-1 Family Signaling Pathways.

Authors demonstrated that methionine deprivation inhibited glioma cell proliferation via downregulating interleukin 1 receptor antagonist (IL1RN) both in vitro and in vivo, methionine deprivation or knocking down IL1RN induced glioma cell cycle arrest.

Interleukin-1 receptor antagonist (IL1RN) is a potent anti-inflammatory molecule that modulates the biological activity of the proinflammatory cytokine, interleukin-1. The aim of this study was to examine the expression of IL1RN in oral squamous cell carcinomas (OSCCs), and to determine its clinical significance.

Mar 2, 2021 · Interleukin-I receptor antagonist (IL1RN) is an immune modulatory molecule that commonly functions by means of competing the binding site of IL-1R with IL-1. Although it was recently reported that IL1RN is involved in osteoblast differentiation, the role of IL1RN in osteogenesis remains unclear.

Feb 8, 2022 · Targeting the Il1rn+ / Trem1+ macrophage subpopulation via blockade of Trem1 using mLR12 could significantly decrease the aortic rupture rate in mice. We present the first comprehensive analysis...

Feb 8, 2025 · Title: Exosome microRNA-125a-5p derived from epithelium promotes M1 macrophage polarization by targeting IL1RN in chronic obstructive pulmonary disease.

Mar 24, 2022 · Here, we show that the ‘interleukin 1 (IL-1)–interleukin 1 receptor antagonist (IL-1ra)’ axis regulates vaccine-mediated systemic inflammation in a host-specific manner. In human immune cells, RNA...

Jun 21, 2022 · IL-1α, IL-1β and IL-1RA are highly regulated inflammatory mediators involved in damage- and pathogen-associated molecular pattern (DAMPs and PAMPs), and cell death pathways. Patients with evidence...

Previous studies suggest that interleukin-1 receptor antagonist (IL-1ra) and single nucleotide polymorphisms (SNPs) in the IL1RN gene might influence the risk of post-stroke infection and outcome. In this study, we addressed the effects of the …