Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells [3] and …

The CXC chemokine interleukin (IL)-8, is a potent neutrophil recruiting and activating factor and the detection of IL-8 in clinical samples from patients with these diseases has led clinicians to …

Jul 7, 2021 · Interleukin 8 (IL-8) is a promising marker for many clinical conditions and currently being applied by various subspecialties of medicine either for the purpose of rapid diagnosis or …

Interleukin-8 (IL-8) is a chemoattractant cytokine produced by a variety of tissue and blood cells. Unlike many other cytokines, it has a distinct target specificity for the neutrophil, with only …

May 1, 2022 · IL-8/CXCL8 is the first chemokine discovered. IL-8 acts on CXCR1/2 to control target cell adhesion, migration, and function. IL-8 is a crucial regulator of neutrophil trafficking …

Mar 11, 2025 · IL-8 supports cell proliferation in an auto- as well as paracrine manner. IL-8 promotes EMT, cell migration, invasion, angiogenesis and leads to metastasis. IL-8 is a target …

Herein, we will review the effects of IL-8 in tumor biology, the ways that IL-8 affects responses to current therapies, and the novel therapeutics targeting the IL-8/IL-8R axis that are currently in …

There appear to be two IL-8 receptors: IL-8Rα (selective for IL-8) and IL-8Rβ (binds to GRO molecules and IL-8 indiscriminantly). It is conceivable that the different IL-8 receptor subtypes, …

A sufficient response of neutrophil granulocytes stimulated by interleukin (IL)-8 is vital during systemic inflammation, for example, in sepsis or severe trauma. Moreover, IL-8 is clinically …

Interleukin-8 (IL-8) is a cytokine produced by macrophages, monocytes, and stromal cells. Both tumor and tumor-associated stromal cells can upregulate production of IL-8, causing MDSCs …