Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells [3] and endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel–Palade bodies.

Interleukin-8 (IL-8) is a chemoattractant cytokine produced by a variety of tissue and blood cells. Unlike many other cytokines, it has a distinct target specificity for the neutrophil, with only weak effects on other blood cells.

Interleukin-8 (IL-8) is one of the major mediators of the inflammatory response. It is secreted by several cell types and functions as a chemoattractant and as a potent angiogenic factor. It is similar to IL-6 but has a longer half-life. Many studies have evaluated the use of IL-8 as an early-phase biomarker.

The CXC chemokine interleukin (IL)-8, is a potent neutrophil recruiting and activating factor and the detection of IL-8 in clinical samples from patients with these diseases has led clinicians to believe that antagonism of IL-8 may be a practicable therapeutic strategy for …

May 1, 2022 · IL-8 was initially characterized as a chemoattractant of neutrophils engaged in acute inflammation and then discovered to also be chemotactic for endothelial cells with a major role in angiogenesis. These two activities of IL-8 foster its stimulatory effect on tumor growth.

IL-8, also known as C-X-C motif chemokine ligand 8 (CXCL8), is a pro-inflammatory chemokine, a member of the CXC family of chemokines, produced under inflammatory conditions by immune and other cell types .

Jul 7, 2021 · Interleukin-8 is a chemotactic agent for monocytes and neutrophils. Interleukin 8 causes oxygen radical and enzyme release by neutrophils and mobilizes products into circulation. Interleukin 8 is stimulated by Interleukin 1 and Tumor Necrosis Factor.

Interleukin-8 (IL-8), a member of the CXC chemokine family, is an important activator and chemoattractant for neutrophils and has been implicated in a variety of inflammatory diseases. IL-8 is secreted in a stimulus-specific manner by a wide variety of cell types and is regulated primarily at the le …

Herein, we will review the effects of IL-8 in tumor biology, the ways that IL-8 affects responses to current therapies, and the novel therapeutics targeting the IL-8/IL-8R axis that are currently in development.

IL-8 was first identified in 1987 as a potent, proinflammatory chemokine, which induces trafficking of neutrophils across the vascular wall (chemotaxis) (Table 58-16).121 This molecule belongs to a chemokine superfamily whose members include neutrophil-activating peptide-2, platelet factor-4, growth-related cytokine (GRO) (also known as ...