The interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2.

Signaling downstream of the IL-2 receptor (IL-2R): (a) Janus kinase-signal transducer and activator of transcription (JAK-STAT) signal transduction. The IL-2Rβ chain couples to JAK1, …

Sep 1, 2020 · The interleukin (IL)-2 receptor (IL-2R) α-chain (CD25) is being shed upon immune activation. Increased levels of soluble (s)IL-2R, therefore, are considered as an indication of …

IL-2 receptor (IL-2R) is considered as a heterotrimeric protein that represents three subunits or chains: α (CD25), β (CD122) and γ (CD132). The different and separate expressions of these …

Aug 8, 2018 · Mechanistically, IL-2 initially interacts with IL-2Rα, resulting in a conformational change in IL-2 so that it can then efficiently interact with and recruit IL-2Rβ.

Interleukin-2 receptor (IL-2R) signaling regulates tolerance and immunity. Here, we review recent work concerning the structure, signaling, and function of the IL-2R, emphasizing the …

Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway plays a pivotal role within these processes. The most striking functions of the IL-2 – IL-2R pathway are …

Mar 17, 2025 · The discovery of interleukin-2 (IL-2) and its receptor (IL-2R) almost 50 years ago revolutionized immunology, marking a pivotal moment in understanding T cell biology and …

Mar 12, 2024 · Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) supports the development and homeostasis of regulatory T cells and contributes to the …

The receptor for IL-2 consists of at least three distinct subunits, the alpha chain (IL-2R alpha), the beta chain (IL-2R beta), and the gamma chain (IL-2R gamma). Although the role of IL-2R …